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Sequence and structural patterns detected in entangled proteins reveal the importance of co-translational folding

Proteins must fold quickly to acquire their biologically functional three-dimensional native structures. Hence, these are mainly stabilized by local contacts, while intricate topologies such as knots are rare. Here, we reveal the existence of specific patterns adopted by protein sequences and struct...

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Detalles Bibliográficos
Autores principales: Baiesi, Marco, Orlandini, Enzo, Seno, Flavio, Trovato, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557820/
https://www.ncbi.nlm.nih.gov/pubmed/31182755
http://dx.doi.org/10.1038/s41598-019-44928-3