Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

The pathological mechanisms of radiation ulcer remain unsolved and there is currently no effective medicine. Here, we demonstrate that persistent DNA damage foci and cell senescence are involved in radiation ulcer development. Further more, we identify cordycepin, a natural nucleoside analogue, as a...

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Detalles Bibliográficos
Autores principales: Wang, Ziwen, Chen, Zelin, Jiang, Zhongyong, Luo, Peng, Liu, Lang, Huang, Yu, Wang, Huilan, Wang, Yu, Long, Lei, Tan, Xu, Liu, Dengqun, Jin, Taotao, Wang, Yawei, Wang, Yang, Liao, Fengying, Zhang, Chi, Chen, Long, Gan, Yibo, Liu, Yunsheng, Yang, Fan, Huang, Chunji, Miao, Hongming, Chen, Jieping, Cheng, Tianmin, Fu, Xiaobing, Shi, Chunmeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557849/
https://www.ncbi.nlm.nih.gov/pubmed/31182708
http://dx.doi.org/10.1038/s41467-019-10386-8

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