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Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase

The suppressor of cytokine signaling 2 (SOCS2) acts as substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex. SOCS2 binds to phosphotyrosine-modified epitopes as degrons for ubiquitination and proteasomal degradation, yet the molecular basis of substrate recognition has remained elu...

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Detalles Bibliográficos
Autores principales:	Kung, Wei-Wei, Ramachandran, Sarath, Makukhin, Nikolai, Bruno, Elvira, Ciulli, Alessio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557900/ https://www.ncbi.nlm.nih.gov/pubmed/31182716 http://dx.doi.org/10.1038/s41467-019-10190-4

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