Cargando…

The MAP3K7-mTOR Axis Promotes the Proliferation and Malignancy of Hepatocellular Carcinoma Cells

Targeted therapy is currently limited for patients with hepatocellular carcinoma (HCC) due to the lack of suitable targets. Kinases play pivotal roles in many cellular biological processes, whereas dysregulation of kinases may lead to various diseases, particularly cancer. However, the role of kinas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Jin-Shiung, Tsai, Wei-Lun, Liu, Pei-Feng, Goan, Yih-Gang, Lin, Chih-Wen, Tseng, Ho-Hsing, Lee, Cheng-Hsin, Shu, Chih-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558008/ https://www.ncbi.nlm.nih.gov/pubmed/31214512 http://dx.doi.org/10.3389/fonc.2019.00474

Ejemplares similares

Involvement of Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and the PI3K/AKT/mTOR Pathway in Nobiletin-Induced Apoptosis of Human Bladder Cancer Cells
por: Goan, Yih-Gang, et al.
Publicado: (2019)

Sofosbuvir induces gene expression for promoting cell proliferation and migration of hepatocellular carcinoma cells
por: Tsai, Wei-Lun, et al.
Publicado: (2022)

Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy
por: Liu, Pei-Feng, et al.
Publicado: (2018)

Kinome-Wide Screening with Small Interfering RNA Identified Polo-like Kinase 1 as a Key Regulator of Proliferation in Oral Cancer Cells
por: Goan, Yih-Gang, et al.
Publicado: (2019)

NPRL2 down‐regulation facilitates the growth of hepatocellular carcinoma via the mTOR pathway and autophagy suppression
por: Wang, Ya‐Chin, et al.
Publicado: (2022)

Hepatitis B Virus X Protein Upregulates mTOR Signaling through IKKβ to Increase Cell Proliferation and VEGF Production in Hepatocellular Carcinoma
por: Yen, Chia-Jui, et al.
Publicado: (2012)

Effects of the mTOR inhibitor Rapamycin on Monocyte-Secreted Chemokines
por: Lin, Hugo You-Hsien, et al.
Publicado: (2014)

Long term oncological outcome of thymoma and thymic carcinoma – an analysis of 235 cases from a single institution
por: Tseng, Yen-Chiang, et al.
Publicado: (2017)

Correction: Long term oncological outcome of thymoma and thymic carcinoma - an analysis of 235 cases from a single institution
por: Tseng, Yen-Chiang, et al.
Publicado: (2017)

Does size affect the prognosis of resectable thymoma beyond the eighth edition TNM?
por: Tseng, Yen‐Chiang, et al.
Publicado: (2021)

Comparison of the Outcomes between Systematic Lymph Node Dissection and Lobe-Specific Lymph Node Dissection for Stage I Non-small Cell Lung Cancer
por: Huang, Ching-Chun, et al.
Publicado: (2023)

The mTOR–Autophagy Axis and the Control of Metabolism
por: Deleyto-Seldas, Nerea, et al.
Publicado: (2021)

The mTOR–lysosome axis at the centre of ageing
por: Carosi, Julian M., et al.
Publicado: (2021)

Cancer and mTOR inhibitors in kidney transplantation recipients
por: Kao, Chih-Chin, et al.
Publicado: (2018)

PSME4 Activates mTOR Signaling and Promotes the Malignant Progression of Hepatocellular Carcinoma
por: Ge, Sijia, et al.
Publicado: (2022)

Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells
por: Grabinski, Nicole, et al.
Publicado: (2012)

Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling
por: Liu, Feng, et al.
Publicado: (2016)

Roles of Akt and ERK in mTOR-Dependent Antidepressant Effects of Vanillic Acid
por: Chuang, Han-Wen, et al.
Publicado: (2020)

mTOR Regulation of Metabolism in Hematologic Malignancies
por: Mirabilii, Simone, et al.
Publicado: (2020)

mTOR-Dependent Cell Proliferation in the Brain
por: Ryskalin, Larisa, et al.
Publicado: (2017)

Next Generation Sequencing for Potential Regulated Genes and Micro-RNAs of Early Growth Response-1 in the Esophageal Squamous Cell Carcinoma
por: Tseng, Yen-Chiang, et al.
Publicado: (2022)

Assessment of Early Growth Response 1 in Tumor Suppression of Esophageal Squamous Cell Carcinoma
por: Tseng, Yen-Chiang, et al.
Publicado: (2022)

LncRNA NORAD Promotes Proliferation And Inhibits Apoptosis Of Gastric Cancer By Regulating miR-214/Akt/mTOR Axis
por: Tao, Wei, et al.
Publicado: (2019)

Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma
por: Ferrín, Gustavo, et al.
Publicado: (2020)

Regulation of the mTOR-Rac1 axis in platelet function
por: Aslan, Joseph E., et al.
Publicado: (2012)

mTOR/PRAS40 interaction: Hypertrophy or proliferation
por: Völkers, Mirko, et al.
Publicado: (2013)

eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway
por: Sun, Liping, et al.
Publicado: (2021)

Curcumin induces apoptosis by inhibiting BCAT1 expression and mTOR signaling in cytarabine-resistant myeloid leukemia cells
por: Tseng, Yu-Hsin, et al.
Publicado: (2021)

Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
por: Čančer, Matko, et al.
Publicado: (2019)

Epigenetic Regulation of Hepatocellular Carcinoma Progression through the mTOR Signaling Pathway
por: Guo, Mengnan, et al.
Publicado: (2021)

The AMPK-mTOR axis requires increased MALAT1 expression for promoting granulosa cell proliferation in endometriosis
por: Liu, Xuejie, et al.
Publicado: (2021)

Changes of Ghrelin/GOAT axis and mTOR pathway in the hypothalamus after sleeve gastrectomy in obese type-2 diabetes rats
por: Wang, Qiang, et al.
Publicado: (2017)

Demethylation of HIN-1 reverses paclitaxel-resistance of ovarian clear cell carcinoma through the AKT-mTOR signaling pathway
por: Ho, Chih-Ming, et al.
Publicado: (2015)

Association of ATG4B and Phosphorylated ATG4B Proteins with Tumorigenesis and Prognosis in Oral Squamous Cell Carcinoma
por: Liu, Pei-Feng, et al.
Publicado: (2019)

Peroxiredoxin-1 promotes cell proliferation and metastasis through enhancing Akt/mTOR in human osteosarcoma cells
por: Cai, An-Lie, et al.
Publicado: (2017)

mTOR in Viral Hepatitis and Hepatocellular Carcinoma: Function and Treatment
por: Wang, Zhuo, et al.
Publicado: (2014)

Elevation of MAP17 enhances the malignant behavior of cells via the Akt/mTOR pathway in hepatocellular carcinoma
por: Chen, Xinhuang, et al.
Publicado: (2017)

Metformin promotes cell proliferation and osteogenesis under high glucose condition by regulating the ROS-AKT-mTOR axis
por: Zhou, Renyi, et al.
Publicado: (2020)

Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer
por: Ji, Juanli, et al.
Publicado: (2021)

Deciphering the mechanism of PSORI-CM02 in suppressing keratinocyte proliferation through the mTOR/HK2/glycolysis axis
por: Wang, Maojie, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3g9c41qc7egt4mn1artd1f0pa7