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Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model

BACKGROUND: Low back pain (LBP) is the leading global cause of disability and is associated with intervertebral disc degeneration (DD) in some individuals. However, many adults have DD without LBP. Understanding why DD is painful in some and not others may unmask novel therapies for chronic LBP. The...

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Detalles Bibliográficos
Autores principales:	Krock, Emerson, Millecamps, Magali, Anderson, Kathleen M., Srivastava, Akanksha, Reihsen, Troy E., Hari, Pawan, Sun, Yue Ran, Jang, Seon Ho, Wilcox, George L., Belani, Kumar G., Beebe, David S., Ouellet, Jean, Pinto, Manuel R., Kehl, Lois J., Haglund, Lisbet, Stone, Laura S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558025/ https://www.ncbi.nlm.nih.gov/pubmed/31047862 http://dx.doi.org/10.1016/j.ebiom.2019.04.032

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