Perifovea retinal thickness as an ophthalmic biomarker for mild cognitive impairment and early Alzheimer's disease

INTRODUCTION: The aim of this study was to investigate retinal thickness as a biomarker for identifying patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). METHODS: The retinal thickness, utilizing the spectral domain optical coherence tomography, was compared among 73 p...

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Detalles Bibliográficos
Autores principales: Tao, Rui, Lu, Zhaozeng, Ding, Ding, Fu, Shuhao, Hong, Zhen, Liang, Xiaoniu, Zheng, Li, Xiao, Yiqin, Zhao, Qianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Retinal Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558027/
https://www.ncbi.nlm.nih.gov/pubmed/31206006
http://dx.doi.org/10.1016/j.dadm.2019.04.003
Descripción
Sumario:INTRODUCTION: The aim of this study was to investigate retinal thickness as a biomarker for identifying patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). METHODS: The retinal thickness, utilizing the spectral domain optical coherence tomography, was compared among 73 patients with AD, 51 patients with MCI, 67 cognitive normal control (NC) subjects. RESULTS: The retinal thickness of ganglion cell complex and peripapillary retinal nerve fiber layer decreased in both AD and MCI patients, in comparison with NC subjects (AD vs. NC, P < .01; MCI vs. NC, P < .01). The inner retinal layers in macular area in MCI exhibited significant thinning compared with NC (P < .001). Remarkable association was found between the retinal thickness and brain volume (P < .05). Better correlation was seen between the inner perifovea retinal thickness and the hippocampal and entorhinal cortex volume (r: 0.427–0.644, P < .01). DISCUSSION: The retinal thickness, especially the inner retinal layer thickness, is a potentially early AD marker indicating neurodegeneration.

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