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Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk
INTRODUCTION: There is observational evidence that low circulating levels of vitamin B12 are associated with an increased risk of Alzheimer's disease METHODS: We used a two-sample summary-statistics–based Mendelian randomization design to assess the relationship of genetic factors contributing...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558085/ https://www.ncbi.nlm.nih.gov/pubmed/31206009 http://dx.doi.org/10.1016/j.dadm.2019.04.007 |
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author | Gagliano Taliun, Sarah A. |
author_facet | Gagliano Taliun, Sarah A. |
author_sort | Gagliano Taliun, Sarah A. |
collection | PubMed |
description | INTRODUCTION: There is observational evidence that low circulating levels of vitamin B12 are associated with an increased risk of Alzheimer's disease METHODS: We used a two-sample summary-statistics–based Mendelian randomization design to assess the relationship of genetic factors contributing to vitamin B12 with late-onset Alzheimer's disease risk. RESULTS: Our results do not support a causal role of decreased vitamin B12 levels on Alzheimer's disease risk. DISCUSSION: This work encourages research on other modifiable biomarkers for Alzheimer's disease risk. |
format | Online Article Text |
id | pubmed-6558085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-65580852019-06-14 Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk Gagliano Taliun, Sarah A. Alzheimers Dement (Amst) Genetics INTRODUCTION: There is observational evidence that low circulating levels of vitamin B12 are associated with an increased risk of Alzheimer's disease METHODS: We used a two-sample summary-statistics–based Mendelian randomization design to assess the relationship of genetic factors contributing to vitamin B12 with late-onset Alzheimer's disease risk. RESULTS: Our results do not support a causal role of decreased vitamin B12 levels on Alzheimer's disease risk. DISCUSSION: This work encourages research on other modifiable biomarkers for Alzheimer's disease risk. Elsevier 2019-06-06 /pmc/articles/PMC6558085/ /pubmed/31206009 http://dx.doi.org/10.1016/j.dadm.2019.04.007 Text en © 2019 The Author http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Genetics Gagliano Taliun, Sarah A. Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk |
title | Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk |
title_full | Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk |
title_fullStr | Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk |
title_full_unstemmed | Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk |
title_short | Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk |
title_sort | genetic determinants of low vitamin b12 levels in alzheimer's disease risk |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558085/ https://www.ncbi.nlm.nih.gov/pubmed/31206009 http://dx.doi.org/10.1016/j.dadm.2019.04.007 |
work_keys_str_mv | AT gaglianotaliunsaraha geneticdeterminantsoflowvitaminb12levelsinalzheimersdiseaserisk |