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Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk

INTRODUCTION: There is observational evidence that low circulating levels of vitamin B12 are associated with an increased risk of Alzheimer's disease METHODS: We used a two-sample summary-statistics–based Mendelian randomization design to assess the relationship of genetic factors contributing...

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Autor principal: Gagliano Taliun, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558085/
https://www.ncbi.nlm.nih.gov/pubmed/31206009
http://dx.doi.org/10.1016/j.dadm.2019.04.007
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author Gagliano Taliun, Sarah A.
author_facet Gagliano Taliun, Sarah A.
author_sort Gagliano Taliun, Sarah A.
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description INTRODUCTION: There is observational evidence that low circulating levels of vitamin B12 are associated with an increased risk of Alzheimer's disease METHODS: We used a two-sample summary-statistics–based Mendelian randomization design to assess the relationship of genetic factors contributing to vitamin B12 with late-onset Alzheimer's disease risk. RESULTS: Our results do not support a causal role of decreased vitamin B12 levels on Alzheimer's disease risk. DISCUSSION: This work encourages research on other modifiable biomarkers for Alzheimer's disease risk.
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spelling pubmed-65580852019-06-14 Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk Gagliano Taliun, Sarah A. Alzheimers Dement (Amst) Genetics INTRODUCTION: There is observational evidence that low circulating levels of vitamin B12 are associated with an increased risk of Alzheimer's disease METHODS: We used a two-sample summary-statistics–based Mendelian randomization design to assess the relationship of genetic factors contributing to vitamin B12 with late-onset Alzheimer's disease risk. RESULTS: Our results do not support a causal role of decreased vitamin B12 levels on Alzheimer's disease risk. DISCUSSION: This work encourages research on other modifiable biomarkers for Alzheimer's disease risk. Elsevier 2019-06-06 /pmc/articles/PMC6558085/ /pubmed/31206009 http://dx.doi.org/10.1016/j.dadm.2019.04.007 Text en © 2019 The Author http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Genetics
Gagliano Taliun, Sarah A.
Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk
title Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk
title_full Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk
title_fullStr Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk
title_full_unstemmed Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk
title_short Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk
title_sort genetic determinants of low vitamin b12 levels in alzheimer's disease risk
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558085/
https://www.ncbi.nlm.nih.gov/pubmed/31206009
http://dx.doi.org/10.1016/j.dadm.2019.04.007
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