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Assessment of patient safety and the efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin in a high-volume liver transplantation center
BACKGROUNDS/AIMS: This study intended to evaluate patient safety and efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin (HBIG) in recipients of hepatitis B virus-associated adult liver transplantation (LT), who visited our outpatien...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Association of Hepato-Biliary-Pancreatic Surgery
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558124/ https://www.ncbi.nlm.nih.gov/pubmed/31225413 http://dx.doi.org/10.14701/ahbps.2019.23.2.128 |
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author | Jeong, I-Ji Hwang, Shin Jung, Dong-Hwan Song, Gi-Won Park, Gil-Chun Ahn, Chul-Soo Moon, Deok-Bog Kim, Ki-Hun Ha, Tae-Yong Ha, Hea-Seon Hong, Jung-Ja Kim, In-Ok Lee, Sung-Gyu |
author_facet | Jeong, I-Ji Hwang, Shin Jung, Dong-Hwan Song, Gi-Won Park, Gil-Chun Ahn, Chul-Soo Moon, Deok-Bog Kim, Ki-Hun Ha, Tae-Yong Ha, Hea-Seon Hong, Jung-Ja Kim, In-Ok Lee, Sung-Gyu |
author_sort | Jeong, I-Ji |
collection | PubMed |
description | BACKGROUNDS/AIMS: This study intended to evaluate patient safety and efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin (HBIG) in recipients of hepatitis B virus-associated adult liver transplantation (LT), who visited our outpatient clinic. METHODS: Our simplified ultra-rapid infusion protocol was to directly infuse 50 ml volume of 10,000 IU HBIG for 20–25 minutes on an ambulatory basis. The incidence of adverse side-effects and the efficiency of facility utilization were assessed retrospectively. RESULTS: A total of 1,513 patients received 12,472 sessions of HBIG infusion according to simplified ultra-rapid infusion method. Of these, 1,172 patients were converted from conventional ultra-rapid infusion method, and received 8,352 sessions of HBIG infusion for 18 months (mean 7.1 times; 4.8 times per year). The remaining 341 de novo patients received 4,120 sessions of HBIG infusion for 18 months (mean 12.1 times; 8.1 times per year). None of these patients experienced any adverse side-effects following the simplified ultra-rapid infusion. The maximal capacity of HBIG infusion sessions at the injection facility of our outpatient clinic was increased from 65–70 sessions to 80 sessions, after introduction of simplified ultra-rapid infusion method. Mean trough anti-HBs titer was lower, and mean interval of HBIG infusion was longer in the combination therapy group compared with HBIG monotherapy group. CONCLUSIONS: Our high-volume study indicates that in nearly all LT recipients, rapid infusion of highly purified HBIG within 30 minutes was well-tolerated. This suggests that it would be reasonable to perform simplified ultra-rapid infusion protocol widely for patient convenience. |
format | Online Article Text |
id | pubmed-6558124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Association of Hepato-Biliary-Pancreatic Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-65581242019-06-20 Assessment of patient safety and the efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin in a high-volume liver transplantation center Jeong, I-Ji Hwang, Shin Jung, Dong-Hwan Song, Gi-Won Park, Gil-Chun Ahn, Chul-Soo Moon, Deok-Bog Kim, Ki-Hun Ha, Tae-Yong Ha, Hea-Seon Hong, Jung-Ja Kim, In-Ok Lee, Sung-Gyu Ann Hepatobiliary Pancreat Surg Original Article BACKGROUNDS/AIMS: This study intended to evaluate patient safety and efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin (HBIG) in recipients of hepatitis B virus-associated adult liver transplantation (LT), who visited our outpatient clinic. METHODS: Our simplified ultra-rapid infusion protocol was to directly infuse 50 ml volume of 10,000 IU HBIG for 20–25 minutes on an ambulatory basis. The incidence of adverse side-effects and the efficiency of facility utilization were assessed retrospectively. RESULTS: A total of 1,513 patients received 12,472 sessions of HBIG infusion according to simplified ultra-rapid infusion method. Of these, 1,172 patients were converted from conventional ultra-rapid infusion method, and received 8,352 sessions of HBIG infusion for 18 months (mean 7.1 times; 4.8 times per year). The remaining 341 de novo patients received 4,120 sessions of HBIG infusion for 18 months (mean 12.1 times; 8.1 times per year). None of these patients experienced any adverse side-effects following the simplified ultra-rapid infusion. The maximal capacity of HBIG infusion sessions at the injection facility of our outpatient clinic was increased from 65–70 sessions to 80 sessions, after introduction of simplified ultra-rapid infusion method. Mean trough anti-HBs titer was lower, and mean interval of HBIG infusion was longer in the combination therapy group compared with HBIG monotherapy group. CONCLUSIONS: Our high-volume study indicates that in nearly all LT recipients, rapid infusion of highly purified HBIG within 30 minutes was well-tolerated. This suggests that it would be reasonable to perform simplified ultra-rapid infusion protocol widely for patient convenience. Korean Association of Hepato-Biliary-Pancreatic Surgery 2019-05 2019-05-31 /pmc/articles/PMC6558124/ /pubmed/31225413 http://dx.doi.org/10.14701/ahbps.2019.23.2.128 Text en Copyright © 2019 by The Korean Association of Hepato-Biliary-Pancreatic Surgery http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jeong, I-Ji Hwang, Shin Jung, Dong-Hwan Song, Gi-Won Park, Gil-Chun Ahn, Chul-Soo Moon, Deok-Bog Kim, Ki-Hun Ha, Tae-Yong Ha, Hea-Seon Hong, Jung-Ja Kim, In-Ok Lee, Sung-Gyu Assessment of patient safety and the efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin in a high-volume liver transplantation center |
title | Assessment of patient safety and the efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin in a high-volume liver transplantation center |
title_full | Assessment of patient safety and the efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin in a high-volume liver transplantation center |
title_fullStr | Assessment of patient safety and the efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin in a high-volume liver transplantation center |
title_full_unstemmed | Assessment of patient safety and the efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin in a high-volume liver transplantation center |
title_short | Assessment of patient safety and the efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin in a high-volume liver transplantation center |
title_sort | assessment of patient safety and the efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis b immunoglobulin in a high-volume liver transplantation center |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558124/ https://www.ncbi.nlm.nih.gov/pubmed/31225413 http://dx.doi.org/10.14701/ahbps.2019.23.2.128 |
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