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Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus
The adipose-derived circulating hormone leptin plays a pivotal role in the control of energy balance and body weight. Sound data indicate that this hormone also acts as an important developmental signal impacting a number of brain regions during fetal and postnatal stages. Leptin levels surge during...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558146/ https://www.ncbi.nlm.nih.gov/pubmed/31213989 http://dx.doi.org/10.3389/fncel.2019.00254 |
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author | Dumon, Camille Pisella, Lucie Diabira, Diabe Belaidouni, Yasmine Wayman, Gary A. Gaiarsa, Jean-Luc |
author_facet | Dumon, Camille Pisella, Lucie Diabira, Diabe Belaidouni, Yasmine Wayman, Gary A. Gaiarsa, Jean-Luc |
author_sort | Dumon, Camille |
collection | PubMed |
description | The adipose-derived circulating hormone leptin plays a pivotal role in the control of energy balance and body weight. Sound data indicate that this hormone also acts as an important developmental signal impacting a number of brain regions during fetal and postnatal stages. Leptin levels surge during the two first postnatal weeks of life in rodents. This period is characterized by the presence of early network driven activity in the immature hippocampus, the so-called Giant Depolarizing Potentials (GDPs). GDPs are thought to contribute to the wiring of the hippocampal network. We therefore tested the effect of leptin on GDPs. Leptin increased GDPs frequency between the postnatal days (P) 1 and 3 via a calcium/Calmodulin-dependent kinase (CaMK) and extracellular signal-related kinase (ERK) dependent pathways. Between P6 and P7, leptin inhibited the frequency of GDPs through the activation of large conductance Ca(2+) activated K(+) (BK) channels driven by a phosphoinositol-3 kinase (PI3K) dependent pathway. These results show that leptin exerts a bi-directional and age-dependent control of GDPs and extends the scope of leptin’s action in the developing brain. |
format | Online Article Text |
id | pubmed-6558146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65581462019-06-18 Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus Dumon, Camille Pisella, Lucie Diabira, Diabe Belaidouni, Yasmine Wayman, Gary A. Gaiarsa, Jean-Luc Front Cell Neurosci Neuroscience The adipose-derived circulating hormone leptin plays a pivotal role in the control of energy balance and body weight. Sound data indicate that this hormone also acts as an important developmental signal impacting a number of brain regions during fetal and postnatal stages. Leptin levels surge during the two first postnatal weeks of life in rodents. This period is characterized by the presence of early network driven activity in the immature hippocampus, the so-called Giant Depolarizing Potentials (GDPs). GDPs are thought to contribute to the wiring of the hippocampal network. We therefore tested the effect of leptin on GDPs. Leptin increased GDPs frequency between the postnatal days (P) 1 and 3 via a calcium/Calmodulin-dependent kinase (CaMK) and extracellular signal-related kinase (ERK) dependent pathways. Between P6 and P7, leptin inhibited the frequency of GDPs through the activation of large conductance Ca(2+) activated K(+) (BK) channels driven by a phosphoinositol-3 kinase (PI3K) dependent pathway. These results show that leptin exerts a bi-directional and age-dependent control of GDPs and extends the scope of leptin’s action in the developing brain. Frontiers Media S.A. 2019-06-04 /pmc/articles/PMC6558146/ /pubmed/31213989 http://dx.doi.org/10.3389/fncel.2019.00254 Text en Copyright © 2019 Dumon, Pisella, Diabira, Belaidouni, Wayman and Gaiarsa. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Dumon, Camille Pisella, Lucie Diabira, Diabe Belaidouni, Yasmine Wayman, Gary A. Gaiarsa, Jean-Luc Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus |
title | Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus |
title_full | Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus |
title_fullStr | Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus |
title_full_unstemmed | Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus |
title_short | Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus |
title_sort | developmental switch of leptin action on network driven activity in the neonatal rat hippocampus |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558146/ https://www.ncbi.nlm.nih.gov/pubmed/31213989 http://dx.doi.org/10.3389/fncel.2019.00254 |
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