A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China

We report a human case of viral encephalitis caused by pseudorabies virus (PRV) in China. A 43-year-old man with no previous medical history presented with high-grade fever, headache and tonic-clonic seizures as well as coma. Plain computer tomography (CT) brain imaging showed hypo-density in the bi...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, HongNa, Han, Hui, Wang, Hao, Cui, Yi, Liu, Han, Ding, ShiFang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558170/
https://www.ncbi.nlm.nih.gov/pubmed/31214104
http://dx.doi.org/10.3389/fneur.2019.00534
_version_ 1783425573307023360
author Yang, HongNa
Han, Hui
Wang, Hao
Cui, Yi
Liu, Han
Ding, ShiFang
author_facet Yang, HongNa
Han, Hui
Wang, Hao
Cui, Yi
Liu, Han
Ding, ShiFang
author_sort Yang, HongNa
collection PubMed
description We report a human case of viral encephalitis caused by pseudorabies virus (PRV) in China. A 43-year-old man with no previous medical history presented with high-grade fever, headache and tonic-clonic seizures as well as coma. Plain computer tomography (CT) brain imaging showed hypo-density in the bilateral basal ganglia, bilateral occipital lobe, bilateral limbic lobe, and left thalamic. Next-generation sequencing (NGS) confirmed the presence of PRV in cerebral spinal fluid (CSF). Regular polymerase chain reaction (PCR) was applied to confirm the presence of PRV in the CSF and blood. In addition, serological (immunological) tests were used to further validate the presence of PRV in the peripheral blood. This case suggested that it was possible for PRV to result in human central nervous system (CNS) infection, and it is necessary for people to increase awareness of self-protection when contacting animals.
format Online
Article
Text
id pubmed-6558170
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-65581702019-06-18 A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China Yang, HongNa Han, Hui Wang, Hao Cui, Yi Liu, Han Ding, ShiFang Front Neurol Neurology We report a human case of viral encephalitis caused by pseudorabies virus (PRV) in China. A 43-year-old man with no previous medical history presented with high-grade fever, headache and tonic-clonic seizures as well as coma. Plain computer tomography (CT) brain imaging showed hypo-density in the bilateral basal ganglia, bilateral occipital lobe, bilateral limbic lobe, and left thalamic. Next-generation sequencing (NGS) confirmed the presence of PRV in cerebral spinal fluid (CSF). Regular polymerase chain reaction (PCR) was applied to confirm the presence of PRV in the CSF and blood. In addition, serological (immunological) tests were used to further validate the presence of PRV in the peripheral blood. This case suggested that it was possible for PRV to result in human central nervous system (CNS) infection, and it is necessary for people to increase awareness of self-protection when contacting animals. Frontiers Media S.A. 2019-06-04 /pmc/articles/PMC6558170/ /pubmed/31214104 http://dx.doi.org/10.3389/fneur.2019.00534 Text en Copyright © 2019 Yang, Han, Wang, Cui, Liu and Ding. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Yang, HongNa
Han, Hui
Wang, Hao
Cui, Yi
Liu, Han
Ding, ShiFang
A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China
title A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China
title_full A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China
title_fullStr A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China
title_full_unstemmed A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China
title_short A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China
title_sort case of human viral encephalitis caused by pseudorabies virus infection in china
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558170/
https://www.ncbi.nlm.nih.gov/pubmed/31214104
http://dx.doi.org/10.3389/fneur.2019.00534
work_keys_str_mv AT yanghongna acaseofhumanviralencephalitiscausedbypseudorabiesvirusinfectioninchina
AT hanhui acaseofhumanviralencephalitiscausedbypseudorabiesvirusinfectioninchina
AT wanghao acaseofhumanviralencephalitiscausedbypseudorabiesvirusinfectioninchina
AT cuiyi acaseofhumanviralencephalitiscausedbypseudorabiesvirusinfectioninchina
AT liuhan acaseofhumanviralencephalitiscausedbypseudorabiesvirusinfectioninchina
AT dingshifang acaseofhumanviralencephalitiscausedbypseudorabiesvirusinfectioninchina
AT yanghongna caseofhumanviralencephalitiscausedbypseudorabiesvirusinfectioninchina
AT hanhui caseofhumanviralencephalitiscausedbypseudorabiesvirusinfectioninchina
AT wanghao caseofhumanviralencephalitiscausedbypseudorabiesvirusinfectioninchina
AT cuiyi caseofhumanviralencephalitiscausedbypseudorabiesvirusinfectioninchina
AT liuhan caseofhumanviralencephalitiscausedbypseudorabiesvirusinfectioninchina
AT dingshifang caseofhumanviralencephalitiscausedbypseudorabiesvirusinfectioninchina

Ejemplares similares