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Validation of MRI for Volumetric Quantification of Atelectasis in the Perioperative Period: An Experimental Study in Swine
Background: Impairment of pulmonary aeration is a frequent postoperative complication that is associated with adverse outcome. Diagnosis and quantification of impaired pulmonary aeration by CT scan is limited due to concern for exposure to ionizing radiation. Magnetic resonance imaging (MRI) represe...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558191/ https://www.ncbi.nlm.nih.gov/pubmed/31214052 http://dx.doi.org/10.3389/fphys.2019.00695 |
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author | Noll, Eric Ohana, Mickael Hengen, Maryse Bennett-Guerrero, Elliott Diana, Michele Giraudeau, Celine Pottecher, Julien Meyer, Nicolas Diemunsch, Pierre |
author_facet | Noll, Eric Ohana, Mickael Hengen, Maryse Bennett-Guerrero, Elliott Diana, Michele Giraudeau, Celine Pottecher, Julien Meyer, Nicolas Diemunsch, Pierre |
author_sort | Noll, Eric |
collection | PubMed |
description | Background: Impairment of pulmonary aeration is a frequent postoperative complication that is associated with adverse outcome. Diagnosis and quantification of impaired pulmonary aeration by CT scan is limited due to concern for exposure to ionizing radiation. Magnetic resonance imaging (MRI) represents a potential radiation-free alternative for this use. We undertook an experimental study to validate the use of MRI to quantify pulmonary aeration impairment. Methods: Ten large white pigs were studied before intubation, after intubation, 2 h after non-protective mechanical ventilation and after intra-tracheal negative pressure suction to induce atelectasis. A lung CT scan immediately followed by a lung MRI were performed at all four time points. On the 40 CT images lung volumes corresponding to non-aerated, poorly aerated, normally aerated, and overinflated voxels were measured based on their radiodensity. Similarly, on the 40 MRI images lung volumes corresponding to non-aerated and aerated voxels were measured based on their signal intensity. The correlation between non-aerated lung by MRI vs., CT scans, and with PaO(2)/FiO(2) measured at each of the four time points was assessed with the Pearson’ correlation coefficient, bias and limits of agreement. Results: Pearson correlation coefficient, bias and limits of agreements between the CT non-aerated lung volumes and MRI abnormal lung volumes were 0.88, -16 ml, and (-108, 77), respectively. Pearson correlation coefficient between PaO(2)/FiO(2) and abnormal lung volumes measured with MRI was -0.60. Conclusion: In a preclinical swine model, quantitative measurements of pulmonary atelectasis by MRI-imaging are well correlated with the gold standard, i.e., densitometric scan CT measurements. |
format | Online Article Text |
id | pubmed-6558191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65581912019-06-18 Validation of MRI for Volumetric Quantification of Atelectasis in the Perioperative Period: An Experimental Study in Swine Noll, Eric Ohana, Mickael Hengen, Maryse Bennett-Guerrero, Elliott Diana, Michele Giraudeau, Celine Pottecher, Julien Meyer, Nicolas Diemunsch, Pierre Front Physiol Physiology Background: Impairment of pulmonary aeration is a frequent postoperative complication that is associated with adverse outcome. Diagnosis and quantification of impaired pulmonary aeration by CT scan is limited due to concern for exposure to ionizing radiation. Magnetic resonance imaging (MRI) represents a potential radiation-free alternative for this use. We undertook an experimental study to validate the use of MRI to quantify pulmonary aeration impairment. Methods: Ten large white pigs were studied before intubation, after intubation, 2 h after non-protective mechanical ventilation and after intra-tracheal negative pressure suction to induce atelectasis. A lung CT scan immediately followed by a lung MRI were performed at all four time points. On the 40 CT images lung volumes corresponding to non-aerated, poorly aerated, normally aerated, and overinflated voxels were measured based on their radiodensity. Similarly, on the 40 MRI images lung volumes corresponding to non-aerated and aerated voxels were measured based on their signal intensity. The correlation between non-aerated lung by MRI vs., CT scans, and with PaO(2)/FiO(2) measured at each of the four time points was assessed with the Pearson’ correlation coefficient, bias and limits of agreement. Results: Pearson correlation coefficient, bias and limits of agreements between the CT non-aerated lung volumes and MRI abnormal lung volumes were 0.88, -16 ml, and (-108, 77), respectively. Pearson correlation coefficient between PaO(2)/FiO(2) and abnormal lung volumes measured with MRI was -0.60. Conclusion: In a preclinical swine model, quantitative measurements of pulmonary atelectasis by MRI-imaging are well correlated with the gold standard, i.e., densitometric scan CT measurements. Frontiers Media S.A. 2019-06-04 /pmc/articles/PMC6558191/ /pubmed/31214052 http://dx.doi.org/10.3389/fphys.2019.00695 Text en Copyright © 2019 Noll, Ohana, Hengen, Bennett-Guerrero, Diana, Giraudeau, Pottecher, Meyer and Diemunsch. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Noll, Eric Ohana, Mickael Hengen, Maryse Bennett-Guerrero, Elliott Diana, Michele Giraudeau, Celine Pottecher, Julien Meyer, Nicolas Diemunsch, Pierre Validation of MRI for Volumetric Quantification of Atelectasis in the Perioperative Period: An Experimental Study in Swine |
title | Validation of MRI for Volumetric Quantification of Atelectasis in the Perioperative Period: An Experimental Study in Swine |
title_full | Validation of MRI for Volumetric Quantification of Atelectasis in the Perioperative Period: An Experimental Study in Swine |
title_fullStr | Validation of MRI for Volumetric Quantification of Atelectasis in the Perioperative Period: An Experimental Study in Swine |
title_full_unstemmed | Validation of MRI for Volumetric Quantification of Atelectasis in the Perioperative Period: An Experimental Study in Swine |
title_short | Validation of MRI for Volumetric Quantification of Atelectasis in the Perioperative Period: An Experimental Study in Swine |
title_sort | validation of mri for volumetric quantification of atelectasis in the perioperative period: an experimental study in swine |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558191/ https://www.ncbi.nlm.nih.gov/pubmed/31214052 http://dx.doi.org/10.3389/fphys.2019.00695 |
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