Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology

Pure total flavonoids from Citrus (PTFC) effectively reduce the symptoms of non-alcoholic fatty liver disease (NAFLD). Our previous microarray analysis uncovered the alterations of important signaling pathways in the treatment of NAFLD with PTFC. However, the underlying core genes that might be targ...

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Autores principales: Hong, Wei, Li, Songsong, Wu, Liyan, He, Beihui, Jiang, Jianping, Chen, Zhiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558193/
https://www.ncbi.nlm.nih.gov/pubmed/31214028
http://dx.doi.org/10.3389/fphar.2019.00582
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author Hong, Wei
Li, Songsong
Wu, Liyan
He, Beihui
Jiang, Jianping
Chen, Zhiyun
author_facet Hong, Wei
Li, Songsong
Wu, Liyan
He, Beihui
Jiang, Jianping
Chen, Zhiyun
author_sort Hong, Wei
collection PubMed
description Pure total flavonoids from Citrus (PTFC) effectively reduce the symptoms of non-alcoholic fatty liver disease (NAFLD). Our previous microarray analysis uncovered the alterations of important signaling pathways in the treatment of NAFLD with PTFC. However, the underlying core genes that might be targeted by PTFC, which play important roles in the progression of NALFD are yet to be identified. In this study, we predicted the vascular endothelial growth factor-C (VEGF-C) as potential key molecular target of PTFC against NAFLD via network pharmacology analysis. The network pharmacology approach presented here provided important clues for understanding the mechanisms of PTFC treatment in the development of NAFLD.
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spelling pubmed-65581932019-06-18 Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology Hong, Wei Li, Songsong Wu, Liyan He, Beihui Jiang, Jianping Chen, Zhiyun Front Pharmacol Pharmacology Pure total flavonoids from Citrus (PTFC) effectively reduce the symptoms of non-alcoholic fatty liver disease (NAFLD). Our previous microarray analysis uncovered the alterations of important signaling pathways in the treatment of NAFLD with PTFC. However, the underlying core genes that might be targeted by PTFC, which play important roles in the progression of NALFD are yet to be identified. In this study, we predicted the vascular endothelial growth factor-C (VEGF-C) as potential key molecular target of PTFC against NAFLD via network pharmacology analysis. The network pharmacology approach presented here provided important clues for understanding the mechanisms of PTFC treatment in the development of NAFLD. Frontiers Media S.A. 2019-06-04 /pmc/articles/PMC6558193/ /pubmed/31214028 http://dx.doi.org/10.3389/fphar.2019.00582 Text en Copyright © 2019 Hong, Li, Wu, He, Jiang and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Hong, Wei
Li, Songsong
Wu, Liyan
He, Beihui
Jiang, Jianping
Chen, Zhiyun
Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology
title Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology
title_full Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology
title_fullStr Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology
title_full_unstemmed Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology
title_short Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology
title_sort prediction of vegf-c as a key target of pure total flavonoids from citrus against nafld in mice via network pharmacology
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558193/
https://www.ncbi.nlm.nih.gov/pubmed/31214028
http://dx.doi.org/10.3389/fphar.2019.00582
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