Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D(2) Receptor

LASSBio-579, an N-phenylpiperazine antipsychotic lead compound, has been previously reported as a D(2) receptor (D(2)R) ligand with antipsychotic-like activities in rodent models of schizophrenia. In order to better understand the molecular mechanism of action of LASSBio-579 and of its main metaboli...

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Detalles Bibliográficos
Autores principales: Silva, Rafaela R., Parreiras-e-Silva, Lucas T., Pompeu, Thais E.T., Duarte, Diego A., Fraga, Carlos A.M., Barreiro, Eliezer J., Menegatti, Ricardo, Costa-Neto, Claudio M., Noël, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558205/
https://www.ncbi.nlm.nih.gov/pubmed/31214037
http://dx.doi.org/10.3389/fphar.2019.00628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558205/
https://www.ncbi.nlm.nih.gov/pubmed/31214037
http://dx.doi.org/10.3389/fphar.2019.00628

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