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Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1

BACKGROUND: A newly developed drug trastuzumab emtansine (T-DM1) has improved the survival of breast cancer (BC) patients. Despite an impressive initial clinical response, a subgroup of patient develop resistance and present therapeutic challenges. The underlying resistance mechanisms are not fully...

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Detalles Bibliográficos
Autores principales:	Islam, Syed S., Uddin, Mohammed, Noman, Abu Shadat M., Akter, Hosneara, Dity, Nusrat J., Basiruzzman, Mohammad, Uddin, Furkan, Ahsan, Jahanara, Annoor, Sunera, Alaiya, Ayodele A., Al-Alwan, Monther, Yeger, Herman, Farhat, Walid A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558306/ https://www.ncbi.nlm.nih.gov/pubmed/31085100 http://dx.doi.org/10.1016/j.ebiom.2019.04.061

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