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Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome

OBJECTIVE: We aimed to compare the first trimester screening profiles of spontaneous (n=972) and in in vitro fertilization (IVF) pregnancies (n=339) in a population of patients who had uncomplicated singleton pregnancies comparable for maternal age, gestation, body mass index, and ethnicity. MATERIA...

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Autores principales: Güzel, Yılmaz, Türkgeldi, Engin, Yağmur, Hande, Salar, Zeki, Balaban, Başak, Urman, Bülent, Öktem, Özgür
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558359/
https://www.ncbi.nlm.nih.gov/pubmed/30206047
http://dx.doi.org/10.4274/jtgga.galenos.2018.2017.0133
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author Güzel, Yılmaz
Türkgeldi, Engin
Yağmur, Hande
Salar, Zeki
Balaban, Başak
Urman, Bülent
Öktem, Özgür
author_facet Güzel, Yılmaz
Türkgeldi, Engin
Yağmur, Hande
Salar, Zeki
Balaban, Başak
Urman, Bülent
Öktem, Özgür
author_sort Güzel, Yılmaz
collection PubMed
description OBJECTIVE: We aimed to compare the first trimester screening profiles of spontaneous (n=972) and in in vitro fertilization (IVF) pregnancies (n=339) in a population of patients who had uncomplicated singleton pregnancies comparable for maternal age, gestation, body mass index, and ethnicity. MATERIAL AND METHODS: A non-interventional analysis of retrospective cohort data and review of the literature. RESULTS: All IVF pregnancies were achieved via intracytoplasmic sperm injection using the same ovarian stimulation protocol with recombinant follicle-stimulating hormone and a gonadotropin-releasing hormone antagonist, cetrorelix acetate. The means of the multiple of median (MoM) of pregnancy-associated plasma protein-A (PAPP-A) were slightly lower in the fresh (1.19±0.6 vs 1.33±0.7, respectively; p=0.056) and frozen embryo transfer (1.03±0.5 vs 1.33±0.7, respectively; p=0.036) IVF pregnancies compared with natural conceptions. However, when the medians of the MoMs of PAPP-A and beta-human chorionic gonadotrophin (β-hCG), and their distributions were compared across the mode of conception, there were no differences between IVF pregnancies spontaneous pregnancies. Furthermore, the scatterplot diagram and curve fitting regression analyses revealed no difference in the temporal relations of β-hCG and PAPP-A with each other and gestational age between spontaneous and IVF pregnancies. CONCLUSION: These results support the notion that uncomplicated singleton IVF pregnancies have similar first trimester screening profiles to spontaneous onceptions.
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spelling pubmed-65583592019-06-19 Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome Güzel, Yılmaz Türkgeldi, Engin Yağmur, Hande Salar, Zeki Balaban, Başak Urman, Bülent Öktem, Özgür J Turk Ger Gynecol Assoc Original Investigation OBJECTIVE: We aimed to compare the first trimester screening profiles of spontaneous (n=972) and in in vitro fertilization (IVF) pregnancies (n=339) in a population of patients who had uncomplicated singleton pregnancies comparable for maternal age, gestation, body mass index, and ethnicity. MATERIAL AND METHODS: A non-interventional analysis of retrospective cohort data and review of the literature. RESULTS: All IVF pregnancies were achieved via intracytoplasmic sperm injection using the same ovarian stimulation protocol with recombinant follicle-stimulating hormone and a gonadotropin-releasing hormone antagonist, cetrorelix acetate. The means of the multiple of median (MoM) of pregnancy-associated plasma protein-A (PAPP-A) were slightly lower in the fresh (1.19±0.6 vs 1.33±0.7, respectively; p=0.056) and frozen embryo transfer (1.03±0.5 vs 1.33±0.7, respectively; p=0.036) IVF pregnancies compared with natural conceptions. However, when the medians of the MoMs of PAPP-A and beta-human chorionic gonadotrophin (β-hCG), and their distributions were compared across the mode of conception, there were no differences between IVF pregnancies spontaneous pregnancies. Furthermore, the scatterplot diagram and curve fitting regression analyses revealed no difference in the temporal relations of β-hCG and PAPP-A with each other and gestational age between spontaneous and IVF pregnancies. CONCLUSION: These results support the notion that uncomplicated singleton IVF pregnancies have similar first trimester screening profiles to spontaneous onceptions. Galenos Publishing 2019-06 2019-05-28 /pmc/articles/PMC6558359/ /pubmed/30206047 http://dx.doi.org/10.4274/jtgga.galenos.2018.2017.0133 Text en © Copyright 2019 by the Turkish-German Gynecological Education and Research Foundation http://creativecommons.org/licenses/by/2.5/ Journal of the Turkish-German Gynecological Association published by Galenos Publishing House.
spellingShingle Original Investigation
Güzel, Yılmaz
Türkgeldi, Engin
Yağmur, Hande
Salar, Zeki
Balaban, Başak
Urman, Bülent
Öktem, Özgür
Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome
title Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome
title_full Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome
title_fullStr Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome
title_full_unstemmed Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome
title_short Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome
title_sort spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for down syndrome
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558359/
https://www.ncbi.nlm.nih.gov/pubmed/30206047
http://dx.doi.org/10.4274/jtgga.galenos.2018.2017.0133
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