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Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome
OBJECTIVE: We aimed to compare the first trimester screening profiles of spontaneous (n=972) and in in vitro fertilization (IVF) pregnancies (n=339) in a population of patients who had uncomplicated singleton pregnancies comparable for maternal age, gestation, body mass index, and ethnicity. MATERIA...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558359/ https://www.ncbi.nlm.nih.gov/pubmed/30206047 http://dx.doi.org/10.4274/jtgga.galenos.2018.2017.0133 |
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author | Güzel, Yılmaz Türkgeldi, Engin Yağmur, Hande Salar, Zeki Balaban, Başak Urman, Bülent Öktem, Özgür |
author_facet | Güzel, Yılmaz Türkgeldi, Engin Yağmur, Hande Salar, Zeki Balaban, Başak Urman, Bülent Öktem, Özgür |
author_sort | Güzel, Yılmaz |
collection | PubMed |
description | OBJECTIVE: We aimed to compare the first trimester screening profiles of spontaneous (n=972) and in in vitro fertilization (IVF) pregnancies (n=339) in a population of patients who had uncomplicated singleton pregnancies comparable for maternal age, gestation, body mass index, and ethnicity. MATERIAL AND METHODS: A non-interventional analysis of retrospective cohort data and review of the literature. RESULTS: All IVF pregnancies were achieved via intracytoplasmic sperm injection using the same ovarian stimulation protocol with recombinant follicle-stimulating hormone and a gonadotropin-releasing hormone antagonist, cetrorelix acetate. The means of the multiple of median (MoM) of pregnancy-associated plasma protein-A (PAPP-A) were slightly lower in the fresh (1.19±0.6 vs 1.33±0.7, respectively; p=0.056) and frozen embryo transfer (1.03±0.5 vs 1.33±0.7, respectively; p=0.036) IVF pregnancies compared with natural conceptions. However, when the medians of the MoMs of PAPP-A and beta-human chorionic gonadotrophin (β-hCG), and their distributions were compared across the mode of conception, there were no differences between IVF pregnancies spontaneous pregnancies. Furthermore, the scatterplot diagram and curve fitting regression analyses revealed no difference in the temporal relations of β-hCG and PAPP-A with each other and gestational age between spontaneous and IVF pregnancies. CONCLUSION: These results support the notion that uncomplicated singleton IVF pregnancies have similar first trimester screening profiles to spontaneous onceptions. |
format | Online Article Text |
id | pubmed-6558359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-65583592019-06-19 Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome Güzel, Yılmaz Türkgeldi, Engin Yağmur, Hande Salar, Zeki Balaban, Başak Urman, Bülent Öktem, Özgür J Turk Ger Gynecol Assoc Original Investigation OBJECTIVE: We aimed to compare the first trimester screening profiles of spontaneous (n=972) and in in vitro fertilization (IVF) pregnancies (n=339) in a population of patients who had uncomplicated singleton pregnancies comparable for maternal age, gestation, body mass index, and ethnicity. MATERIAL AND METHODS: A non-interventional analysis of retrospective cohort data and review of the literature. RESULTS: All IVF pregnancies were achieved via intracytoplasmic sperm injection using the same ovarian stimulation protocol with recombinant follicle-stimulating hormone and a gonadotropin-releasing hormone antagonist, cetrorelix acetate. The means of the multiple of median (MoM) of pregnancy-associated plasma protein-A (PAPP-A) were slightly lower in the fresh (1.19±0.6 vs 1.33±0.7, respectively; p=0.056) and frozen embryo transfer (1.03±0.5 vs 1.33±0.7, respectively; p=0.036) IVF pregnancies compared with natural conceptions. However, when the medians of the MoMs of PAPP-A and beta-human chorionic gonadotrophin (β-hCG), and their distributions were compared across the mode of conception, there were no differences between IVF pregnancies spontaneous pregnancies. Furthermore, the scatterplot diagram and curve fitting regression analyses revealed no difference in the temporal relations of β-hCG and PAPP-A with each other and gestational age between spontaneous and IVF pregnancies. CONCLUSION: These results support the notion that uncomplicated singleton IVF pregnancies have similar first trimester screening profiles to spontaneous onceptions. Galenos Publishing 2019-06 2019-05-28 /pmc/articles/PMC6558359/ /pubmed/30206047 http://dx.doi.org/10.4274/jtgga.galenos.2018.2017.0133 Text en © Copyright 2019 by the Turkish-German Gynecological Education and Research Foundation http://creativecommons.org/licenses/by/2.5/ Journal of the Turkish-German Gynecological Association published by Galenos Publishing House. |
spellingShingle | Original Investigation Güzel, Yılmaz Türkgeldi, Engin Yağmur, Hande Salar, Zeki Balaban, Başak Urman, Bülent Öktem, Özgür Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome |
title | Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome |
title_full | Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome |
title_fullStr | Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome |
title_full_unstemmed | Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome |
title_short | Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome |
title_sort | spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for down syndrome |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558359/ https://www.ncbi.nlm.nih.gov/pubmed/30206047 http://dx.doi.org/10.4274/jtgga.galenos.2018.2017.0133 |
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