Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins

Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galec...

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Detalles Bibliográficos
Autores principales: Blois, Sandra M., Dveksler, Gabriela, Vasta, Gerardo R., Freitag, Nancy, Blanchard, Véronique, Barrientos, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558399/
https://www.ncbi.nlm.nih.gov/pubmed/31231368
http://dx.doi.org/10.3389/fimmu.2019.01166
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author Blois, Sandra M.
Dveksler, Gabriela
Vasta, Gerardo R.
Freitag, Nancy
Blanchard, Véronique
Barrientos, Gabriela
author_facet Blois, Sandra M.
Dveksler, Gabriela
Vasta, Gerardo R.
Freitag, Nancy
Blanchard, Véronique
Barrientos, Gabriela
author_sort Blois, Sandra M.
collection PubMed
description Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.
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spelling pubmed-65583992019-06-21 Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins Blois, Sandra M. Dveksler, Gabriela Vasta, Gerardo R. Freitag, Nancy Blanchard, Véronique Barrientos, Gabriela Front Immunol Immunology Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders. Frontiers Media S.A. 2019-05-29 /pmc/articles/PMC6558399/ /pubmed/31231368 http://dx.doi.org/10.3389/fimmu.2019.01166 Text en Copyright © 2019 Blois, Dveksler, Vasta, Freitag, Blanchard and Barrientos. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Blois, Sandra M.
Dveksler, Gabriela
Vasta, Gerardo R.
Freitag, Nancy
Blanchard, Véronique
Barrientos, Gabriela
Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
title Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
title_full Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
title_fullStr Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
title_full_unstemmed Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
title_short Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
title_sort pregnancy galectinology: insights into a complex network of glycan binding proteins
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558399/
https://www.ncbi.nlm.nih.gov/pubmed/31231368
http://dx.doi.org/10.3389/fimmu.2019.01166
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