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Hyperthermic intraperitoneal chemotherapy (HIPEC) in combined treatment of locally advanced and intraperitonealy disseminated gastric cancer: A retrospective cooperative Central‐Eastern European study
BACKGROUND AND OBJECTIVES: Clinical experience in Western Europe suggests that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are promising methods in the management of gastric cancer (GC) with peritoneal metastases. However, there are almost no data on such treatm...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558472/ https://www.ncbi.nlm.nih.gov/pubmed/31033239 http://dx.doi.org/10.1002/cam4.2204 |
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author | Yarema, Roman Mielko, Jerzy Fetsych, Taras Ohorchak, Myron Skorzewska, Magdalena Rawicz‐Pruszyński, Karol Mashukov, Artem Maksimovsky, Viatcheslav Jastrzębski, Tomasz Polkowski, Wojciech Gyrya, Petro Kovalchuk, Yuriy Safiyan, Victor Karelin, Ivan Kopetskiy, Viatcheslav Kolesnik, Olena Kondratskiy, Yuriy Paskonis, Marius |
author_facet | Yarema, Roman Mielko, Jerzy Fetsych, Taras Ohorchak, Myron Skorzewska, Magdalena Rawicz‐Pruszyński, Karol Mashukov, Artem Maksimovsky, Viatcheslav Jastrzębski, Tomasz Polkowski, Wojciech Gyrya, Petro Kovalchuk, Yuriy Safiyan, Victor Karelin, Ivan Kopetskiy, Viatcheslav Kolesnik, Olena Kondratskiy, Yuriy Paskonis, Marius |
author_sort | Yarema, Roman |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Clinical experience in Western Europe suggests that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are promising methods in the management of gastric cancer (GC) with peritoneal metastases. However, there are almost no data on such treatment results in patient from Central‐Eastern European population. METHODS: A retrospective cooperative study was performed at 6 Central‐Eastern European HIPEC centers. HIPEC was used in 117 patients for the following indications: treatment of GC with limited overt peritoneal metastases (n = 70), adjuvant setting after radical gastrectomy (n = 37) and palliative approach for elimination of severe ascites without gastrectomy (n = 10). RESULTS: Postoperative morbidity and mortality rates were 29.1% and 5.1%, respectively. Median overall survival in the groups with therapeutic, adjuvant, and palliative indications was 12.6, 34, and 3.5 months. The only long‐term survivors occurred in the group with peritoneal cancer index (PCI) of 0‐6 points without survival difference in groups with PCI 7‐12 vs PCI 13 or more points. CONCLUSIONS: GC patients with limited peritoneal metastases can benefit from CRS + HIPEC. Hyperthermic intraperitoneal chemotherapy could be an effective method of adjuvant treatment of GC with a high risk of intraperitoneal progression. No long‐term survival may be expected after palliative approach to HIPEC. |
format | Online Article Text |
id | pubmed-6558472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65584722019-06-13 Hyperthermic intraperitoneal chemotherapy (HIPEC) in combined treatment of locally advanced and intraperitonealy disseminated gastric cancer: A retrospective cooperative Central‐Eastern European study Yarema, Roman Mielko, Jerzy Fetsych, Taras Ohorchak, Myron Skorzewska, Magdalena Rawicz‐Pruszyński, Karol Mashukov, Artem Maksimovsky, Viatcheslav Jastrzębski, Tomasz Polkowski, Wojciech Gyrya, Petro Kovalchuk, Yuriy Safiyan, Victor Karelin, Ivan Kopetskiy, Viatcheslav Kolesnik, Olena Kondratskiy, Yuriy Paskonis, Marius Cancer Med Clinical Cancer Research BACKGROUND AND OBJECTIVES: Clinical experience in Western Europe suggests that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are promising methods in the management of gastric cancer (GC) with peritoneal metastases. However, there are almost no data on such treatment results in patient from Central‐Eastern European population. METHODS: A retrospective cooperative study was performed at 6 Central‐Eastern European HIPEC centers. HIPEC was used in 117 patients for the following indications: treatment of GC with limited overt peritoneal metastases (n = 70), adjuvant setting after radical gastrectomy (n = 37) and palliative approach for elimination of severe ascites without gastrectomy (n = 10). RESULTS: Postoperative morbidity and mortality rates were 29.1% and 5.1%, respectively. Median overall survival in the groups with therapeutic, adjuvant, and palliative indications was 12.6, 34, and 3.5 months. The only long‐term survivors occurred in the group with peritoneal cancer index (PCI) of 0‐6 points without survival difference in groups with PCI 7‐12 vs PCI 13 or more points. CONCLUSIONS: GC patients with limited peritoneal metastases can benefit from CRS + HIPEC. Hyperthermic intraperitoneal chemotherapy could be an effective method of adjuvant treatment of GC with a high risk of intraperitoneal progression. No long‐term survival may be expected after palliative approach to HIPEC. John Wiley and Sons Inc. 2019-04-29 /pmc/articles/PMC6558472/ /pubmed/31033239 http://dx.doi.org/10.1002/cam4.2204 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Yarema, Roman Mielko, Jerzy Fetsych, Taras Ohorchak, Myron Skorzewska, Magdalena Rawicz‐Pruszyński, Karol Mashukov, Artem Maksimovsky, Viatcheslav Jastrzębski, Tomasz Polkowski, Wojciech Gyrya, Petro Kovalchuk, Yuriy Safiyan, Victor Karelin, Ivan Kopetskiy, Viatcheslav Kolesnik, Olena Kondratskiy, Yuriy Paskonis, Marius Hyperthermic intraperitoneal chemotherapy (HIPEC) in combined treatment of locally advanced and intraperitonealy disseminated gastric cancer: A retrospective cooperative Central‐Eastern European study |
title | Hyperthermic intraperitoneal chemotherapy (HIPEC) in combined treatment of locally advanced and intraperitonealy disseminated gastric cancer: A retrospective cooperative Central‐Eastern European study |
title_full | Hyperthermic intraperitoneal chemotherapy (HIPEC) in combined treatment of locally advanced and intraperitonealy disseminated gastric cancer: A retrospective cooperative Central‐Eastern European study |
title_fullStr | Hyperthermic intraperitoneal chemotherapy (HIPEC) in combined treatment of locally advanced and intraperitonealy disseminated gastric cancer: A retrospective cooperative Central‐Eastern European study |
title_full_unstemmed | Hyperthermic intraperitoneal chemotherapy (HIPEC) in combined treatment of locally advanced and intraperitonealy disseminated gastric cancer: A retrospective cooperative Central‐Eastern European study |
title_short | Hyperthermic intraperitoneal chemotherapy (HIPEC) in combined treatment of locally advanced and intraperitonealy disseminated gastric cancer: A retrospective cooperative Central‐Eastern European study |
title_sort | hyperthermic intraperitoneal chemotherapy (hipec) in combined treatment of locally advanced and intraperitonealy disseminated gastric cancer: a retrospective cooperative central‐eastern european study |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558472/ https://www.ncbi.nlm.nih.gov/pubmed/31033239 http://dx.doi.org/10.1002/cam4.2204 |
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