Tumor suppressive effects of the pleiotropically acting miR-195 in colorectal cancer cells

Downregulation of miR-195 in colorectal cancer tissues has been reported in several studies. We investigated the impact exogenous induction of mature miR-195-5p on some malignant features of human colorectal cancer cells. Caco-2 and SW480 human colon cancer cell lines were transfected with a synthet...

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Detalles Bibliográficos
Autores principales: Forouzan Jahromi, Zahra, Javeri, Arash, Fakhr Taha, Masoumeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558512/
https://www.ncbi.nlm.nih.gov/pubmed/31217787
http://dx.doi.org/10.17179/excli2019-1166
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author Forouzan Jahromi, Zahra
Javeri, Arash
Fakhr Taha, Masoumeh
author_facet Forouzan Jahromi, Zahra
Javeri, Arash
Fakhr Taha, Masoumeh
author_sort Forouzan Jahromi, Zahra
collection PubMed
description Downregulation of miR-195 in colorectal cancer tissues has been reported in several studies. We investigated the impact exogenous induction of mature miR-195-5p on some malignant features of human colorectal cancer cells. Caco-2 and SW480 human colon cancer cell lines were transfected with a synthetic miR-195-5p mimic. Exogenous induction of miR-195-5p suppressed multiple mediators of invasion and angiogenesis in colorectal cancer cells and increased the apoptotic cell population in both cell lines. Also, migration of both cell lines was significantly compromised after miR-195 transfection. Our results are indicating a strong tumor suppressive role for miR-195 in human colorectal cancer.
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spelling pubmed-65585122019-06-19 Tumor suppressive effects of the pleiotropically acting miR-195 in colorectal cancer cells Forouzan Jahromi, Zahra Javeri, Arash Fakhr Taha, Masoumeh EXCLI J Original Article Downregulation of miR-195 in colorectal cancer tissues has been reported in several studies. We investigated the impact exogenous induction of mature miR-195-5p on some malignant features of human colorectal cancer cells. Caco-2 and SW480 human colon cancer cell lines were transfected with a synthetic miR-195-5p mimic. Exogenous induction of miR-195-5p suppressed multiple mediators of invasion and angiogenesis in colorectal cancer cells and increased the apoptotic cell population in both cell lines. Also, migration of both cell lines was significantly compromised after miR-195 transfection. Our results are indicating a strong tumor suppressive role for miR-195 in human colorectal cancer. Leibniz Research Centre for Working Environment and Human Factors 2019-04-09 /pmc/articles/PMC6558512/ /pubmed/31217787 http://dx.doi.org/10.17179/excli2019-1166 Text en Copyright © 2019 Forouzan Jahromi et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Original Article
Forouzan Jahromi, Zahra
Javeri, Arash
Fakhr Taha, Masoumeh
Tumor suppressive effects of the pleiotropically acting miR-195 in colorectal cancer cells
title Tumor suppressive effects of the pleiotropically acting miR-195 in colorectal cancer cells
title_full Tumor suppressive effects of the pleiotropically acting miR-195 in colorectal cancer cells
title_fullStr Tumor suppressive effects of the pleiotropically acting miR-195 in colorectal cancer cells
title_full_unstemmed Tumor suppressive effects of the pleiotropically acting miR-195 in colorectal cancer cells
title_short Tumor suppressive effects of the pleiotropically acting miR-195 in colorectal cancer cells
title_sort tumor suppressive effects of the pleiotropically acting mir-195 in colorectal cancer cells
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558512/
https://www.ncbi.nlm.nih.gov/pubmed/31217787
http://dx.doi.org/10.17179/excli2019-1166
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