Cargando…

Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes

Dysregulation of multiple microRNAs widely takes place during rheumatoid arthritis (RA) and experimental arthritides. This study is performed to explore the possible mechanism underlying DICER1 deficiency-mediated inflammation in human synoviocytes SW982. Firstly, RNAi of DICER1 led to increased COX...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Congshan, Xu, Jing, Zhu, Wenhua, Cai, Yongsong, Wang, Si, Guo, Yuanxu, Xu, Ke, Geng, Manman, Hussain, Nazim, Han, Yan, Zhang, Fujun, Ning, Qilan, Meng, Liesu, Lu, Shemin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558604/ https://www.ncbi.nlm.nih.gov/pubmed/31275058 http://dx.doi.org/10.1155/2019/6768504

Ejemplares similares

Intervening upregulated SLC7A5 could mitigate inflammatory mediator by mTOR-P70S6K signal in rheumatoid arthritis synoviocytes
por: Xu, Jing, et al.
Publicado: (2020)

MicroRNA-497 Reduction and Increase of Its Family Member MicroRNA-424 Lead to Dysregulation of Multiple Inflammation Related Genes in Synovial Fibroblasts With Rheumatoid Arthritis
por: Wang, Si, et al.
Publicado: (2021)

Down‐regulation of miR‐10a‐5p in synoviocytes contributes to TBX5‐controlled joint inflammation
por: Hussain, Nazim, et al.
Publicado: (2017)

Successful Transfection of MicroRNA Mimics or Inhibitors in a Regular Cell Line and in Primary Cells Derived from Patients with Rheumatoid Arthritis
por: Wang, Si, et al.
Publicado: (2023)

Down-regulation of miR-10a-5p promotes proliferation and restricts apoptosis via targeting T-box transcription factor 5 in inflamed synoviocytes
por: Hussain, Nazim, et al.
Publicado: (2018)

Interpreting the MicroRNA-15/107 family: interaction identification by combining network based and experiment supported approach
por: Wang, Si, et al.
Publicado: (2019)

Pleiotropic microRNA-21 in pulmonary remodeling: novel insights for molecular mechanism and present advancements
por: Jiang, Congshan, et al.
Publicado: (2019)

Increased expression of Th17 cytokines and interleukin-22 correlates with disease activity in pristane-induced arthritis in rats
por: Wang, Bo, et al.
Publicado: (2017)

SLC38A6 expression in macrophages exacerbates pulmonary inflammation
por: Peng, Yizhao, et al.
Publicado: (2023)

MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats
por: Jiang, Congshan, et al.
Publicado: (2014)

Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis
por: Guo, Yuanxu, et al.
Publicado: (2018)

IL-22 expression is increased variedly in the initial phase, onset and chronic phase of a pristane-induced arthritis rat model
por: Hou, Weikun, et al.
Publicado: (2017)

Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts
por: Zhu, Wenhua, et al.
Publicado: (2011)

miR-449a inhibits cell proliferation, migration, and inflammation by regulating high-mobility group box protein 1 and forms a mutual inhibition loop with Yin Yang 1 in rheumatoid arthritis fibroblast-like synoviocytes
por: Cai, Yongsong, et al.
Publicado: (2019)

Molecular immune pathogenesis and diagnosis of COVID-19
por: Li, Xiaowei, et al.
Publicado: (2020)

Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats
por: Meng, Liesu, et al.
Publicado: (2010)

Evaluation of immunoprotection against coronavirus disease 2019: Novel variants, vaccine inoculation, and complications
por: Jiang, Congshan, et al.
Publicado: (2023)

Identification of a cartilage specific novel miRNA which directly targets PRMT3 in rats
por: Sun, Jian, et al.
Publicado: (2021)

Selenium‐sensitive miRNA‐181a‐5p targeting SBP2 regulates selenoproteins expression in cartilage
por: Min, Zixin, et al.
Publicado: (2018)

Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing
por: Jiang, Congshan, et al.
Publicado: (2016)

Real-world effectiveness and protection of SARS-CoV-2 vaccine among patients hospitalized for COVID-19 in Xi’an, China, December 8, 2021, to January 20, 2022: A retrospective study
por: Li, Xiaowei, et al.
Publicado: (2022)

Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice
por: Li, Mengyao, et al.
Publicado: (2021)

Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection
por: Jiang, Congshan, et al.
Publicado: (2021)

TLR3 and TLR7 Modulate IgE Production in Antigen Induced Pulmonary Inflammation via Influencing IL-4 Expression in Immune Organs
por: Meng, Liesu, et al.
Publicado: (2011)

Down‐regulated in OA cartilage, SFMBT2 contributes to NF‐κB‐mediated ECM degradation
por: Hussain, Safdar, et al.
Publicado: (2018)

Emerging Roles of T Helper Cells in Non-Infectious Neuroinflammation: Savior or Sinner
por: Liu, Wenbin, et al.
Publicado: (2022)

Design, synthesis, and evaluation of fluoroquinolone derivatives as microRNA-21 small-molecule inhibitors
por: Hei, Yuan-Yuan, et al.
Publicado: (2022)

Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma
por: Zhang, Ning, et al.
Publicado: (2022)

Signaling network between the dysregulated expression of microRNAs and mRNAs in propofol-induced developmental neurotoxicity in mice
por: Jiang, Congshan, et al.
Publicado: (2018)

Dysregulation of Dicer1 in Beta Cells Impairs Islet Architecture and Glucose Metabolism
por: Mandelbaum, Amitai D., et al.
Publicado: (2012)

Natural polymorphism of Ym1 regulates pneumonitis through alternative activation of macrophages
por: Zhu, Wenhua, et al.
Publicado: (2020)

LncRNA WDR11-AS1 Promotes Extracellular Matrix Synthesis in Osteoarthritis by Directly Interacting with RNA-Binding Protein PABPC1 to Stabilize SOX9 Expression
por: Huang, Huang, et al.
Publicado: (2023)

BMP2K dysregulation promotes abnormal megakaryopoiesis in acute megakaryoblastic leukemia
por: Wang, Manman, et al.
Publicado: (2020)

Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis
por: Apellaniz-Ruiz, Maria, et al.
Publicado: (2023)

Cytosolic Phospholipase A2 Regulates TNF-Induced Production of Joint Destructive Effectors in Synoviocytes
por: Sommerfelt, Randi M., et al.
Publicado: (2013)

Topical Treatment of Colquhounia Root Relieves Skin Inflammation and Itch in Imiquimod-Induced Psoriasiform Dermatitis in Mice
por: Li, Fei, et al.
Publicado: (2022)

Dicer Regulates the Balance of Short-Lived Effector and Long-Lived Memory CD8 T Cell Lineages
por: Baumann, Florian M., et al.
Publicado: (2016)

DICER1 Syndrome: DICER1 Mutations in Rare Cancers
por: Robertson, Jake C., et al.
Publicado: (2018)

Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies
por: Theotoki, Eleni I., et al.
Publicado: (2020)

Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax
por: Wang, Bo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ilq9i23lq62p349k7f85k8kpqv