Proteomics of Bordetella pertussis whole-cell and acellular vaccines

OBJECTIVES: Bordetella pertussis is the etiological agent of whooping cough, a bacterial infection of especially children, which may be fatal without treatment. In frame of studies to investigate putative effects of vaccination on host–pathogen interaction and clonal distribution of strains, in addi...

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Detalles Bibliográficos
Autores principales: Möller, Jens, Kraner, Max Edmund, Burkovski, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Data Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558669/
https://www.ncbi.nlm.nih.gov/pubmed/31182148
http://dx.doi.org/10.1186/s13104-019-4373-2
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author Möller, Jens
Kraner, Max Edmund
Burkovski, Andreas
author_facet Möller, Jens
Kraner, Max Edmund
Burkovski, Andreas
author_sort Möller, Jens
collection PubMed
description OBJECTIVES: Bordetella pertussis is the etiological agent of whooping cough, a bacterial infection of especially children, which may be fatal without treatment. In frame of studies to investigate putative effects of vaccination on host–pathogen interaction and clonal distribution of strains, in addition to Corynebacterium diphtheriae and Clostridium tetani toxoid vaccines, also whole-cell and acellular pertussis vaccines were analyzed by mass spectrometry. DATA DESCRIPTION: LC–MS/MS spectra were generated and analyzed using B. pertussis genome data and proteins present in whole-cell and acellular pertussis vaccines were identified. Subcellular localization of proteins and presence of signal peptides was determined bioinformatically.
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spelling pubmed-65586692019-06-13 Proteomics of Bordetella pertussis whole-cell and acellular vaccines Möller, Jens Kraner, Max Edmund Burkovski, Andreas BMC Res Notes Data Note OBJECTIVES: Bordetella pertussis is the etiological agent of whooping cough, a bacterial infection of especially children, which may be fatal without treatment. In frame of studies to investigate putative effects of vaccination on host–pathogen interaction and clonal distribution of strains, in addition to Corynebacterium diphtheriae and Clostridium tetani toxoid vaccines, also whole-cell and acellular pertussis vaccines were analyzed by mass spectrometry. DATA DESCRIPTION: LC–MS/MS spectra were generated and analyzed using B. pertussis genome data and proteins present in whole-cell and acellular pertussis vaccines were identified. Subcellular localization of proteins and presence of signal peptides was determined bioinformatically. BioMed Central 2019-06-10 /pmc/articles/PMC6558669/ /pubmed/31182148 http://dx.doi.org/10.1186/s13104-019-4373-2 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Data Note
Möller, Jens
Kraner, Max Edmund
Burkovski, Andreas
Proteomics of Bordetella pertussis whole-cell and acellular vaccines
title Proteomics of Bordetella pertussis whole-cell and acellular vaccines
title_full Proteomics of Bordetella pertussis whole-cell and acellular vaccines
title_fullStr Proteomics of Bordetella pertussis whole-cell and acellular vaccines
title_full_unstemmed Proteomics of Bordetella pertussis whole-cell and acellular vaccines
title_short Proteomics of Bordetella pertussis whole-cell and acellular vaccines
title_sort proteomics of bordetella pertussis whole-cell and acellular vaccines
topic Data Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558669/
https://www.ncbi.nlm.nih.gov/pubmed/31182148
http://dx.doi.org/10.1186/s13104-019-4373-2
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