In vivo real-time dynamics of ATP and ROS production in axonal mitochondria show decoupling in mouse models of peripheral neuropathies

Mitochondria are critical for the function and maintenance of myelinated axons notably through Adenosine triphosphate (ATP) production. A direct by-product of this ATP production is reactive oxygen species (ROS), which are highly deleterious for neurons. While ATP shortage and ROS levels increase ar...

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Detalles Bibliográficos
Autores principales: van Hameren, Gerben, Campbell, Graham, Deck, Marie, Berthelot, Jade, Gautier, Benoit, Quintana, Patrice, Chrast, Roman, Tricaud, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558672/
https://www.ncbi.nlm.nih.gov/pubmed/31186069
http://dx.doi.org/10.1186/s40478-019-0740-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558672/
https://www.ncbi.nlm.nih.gov/pubmed/31186069
http://dx.doi.org/10.1186/s40478-019-0740-4

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