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In vivo real-time dynamics of ATP and ROS production in axonal mitochondria show decoupling in mouse models of peripheral neuropathies
Mitochondria are critical for the function and maintenance of myelinated axons notably through Adenosine triphosphate (ATP) production. A direct by-product of this ATP production is reactive oxygen species (ROS), which are highly deleterious for neurons. While ATP shortage and ROS levels increase ar...
Autores principales: | van Hameren, Gerben, Campbell, Graham, Deck, Marie, Berthelot, Jade, Gautier, Benoit, Quintana, Patrice, Chrast, Roman, Tricaud, Nicolas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558672/ https://www.ncbi.nlm.nih.gov/pubmed/31186069 http://dx.doi.org/10.1186/s40478-019-0740-4 |
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