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Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans
BACKGROUND: Mutationally activated Ras proteins are closely linked to a wide variety of human cancers. Hence, there has been an intensive search for anti-Ras therapies for cancer treatment. The sole Ras gene, which encodes LET-60, in Caenorhabditis elegans regulates vulval development. While the los...
Autores principales: | Ji, Jiaojiao, Yuan, Jiang, Guo, Xiaoyu, Ji, Ruifang, Quan, Qinghua, Ding, Mei, Li, Xia, Liu, Yonggang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558680/ https://www.ncbi.nlm.nih.gov/pubmed/31198408 http://dx.doi.org/10.1186/s12935-019-0880-4 |
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