Human-induced pluripotent stem cell-derived cardiomyocytes have limited I(Ks) for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker

OBJECTIVE: We investigated if there is I(Ks), and if there is repolarization reserve by I(Ks) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). DESIGN: We used a specific KCNQ1/KCNE1 channel blocker, L-000768673, with an IC(50) of 9 nM, and four hERG-specific blockers, astem...

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Detalles Bibliográficos
Autores principales: Zeng, Haoyu, Wang, Jixin, Clouse, Holly, Lagrutta, Armando, Sannajust, Frederick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558757/
https://www.ncbi.nlm.nih.gov/pubmed/31217965
http://dx.doi.org/10.1177/2048004019854919

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