Cargando…

High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer

BACKGROUND: α3β1 integrin is a promising cancer biomarker and drug target. We previously identified a 9-amino-acid cyclic peptide LXY30 for detecting α3β1 integrin on the surface of live tumor cells. This study was undertaken to characterize LXY30 in the detection, cellular function, imaging, and ta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Wenwu, Ma, Weijie, Wei, Sixi, Li, Qianping, Liu, Ruiwu, Carney, Randy P., Yang, Kevin, Lee, Joyce, Nyugen, Alan, Yoneda, Ken Y., Lam, Kit S., Li, Tianhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558829/ https://www.ncbi.nlm.nih.gov/pubmed/31182116 http://dx.doi.org/10.1186/s13045-019-0740-7

Ejemplares similares

Correction to: High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer
por: Xiao, Wenwu, et al.
Publicado: (2019)

Discovery and characterization of a high-affinity and high-specificity peptide ligand LXY30 for in vivo targeting of α3 integrin-expressing human tumors
por: Xiao, Wenwu, et al.
Publicado: (2016)

High integrin α3 expression is associated with poor prognosis in patients with non-small cell lung cancer
por: Li, Qianping, et al.
Publicado: (2020)

Medical History from the Earliest Times: LXI.—The Organicists
por: Withington, E. T.
Publicado: (1893)

Reports on the Hospitals of the United Kingdom: LXI. York County Hospital
por: Burdett, Henry
Publicado: (1912)

The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells
por: Kalashova, Julia, et al.
Publicado: (2023)

Low-affinity integrin states have faster ligand-binding kinetics than the high-affinity state
por: Li, Jing, et al.
Publicado: (2021)

Developing an Injectable Nanofibrous Extracellular Matrix Hydrogel With an Integrin αvβ3 Ligand to Improve Endothelial Cell Survival, Engraftment and Vascularization
por: Hao, Dake, et al.
Publicado: (2020)

A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand
por: Luo, Bing-Hao, et al.
Publicado: (2004)

One-bead one-compound combinatorial library derived targeting ligands for detection and treatment of oral squamous cancer
por: Yang, Fan, et al.
Publicado: (2019)

Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity
Publicado: (1996)

LXY6090 – a novel manassantin A derivative – limits breast cancer growth through hypoxia-inducible factor-1 inhibition
por: Lai, Fangfang, et al.
Publicado: (2016)

Neutrophil recruitment limited by high-affinity bent β(2) integrin binding ligand in cis
por: Fan, Zhichao, et al.
Publicado: (2016)

Combinatorial Peptide Microarray Synthesis Based on Microfluidic Impact Printing
por: Li, Jiannan, et al.
Publicado: (2018)

Integrin intra-heterodimer affinity inversely correlates with integrin activatability
por: Sun, Guangyu, et al.
Publicado: (2021)

A bioactive material with dual integrin-targeting ligands regulates specific endogenous cell adhesion and promotes vascularized bone regeneration in adult and fetal bone defects
por: Hao, Dake, et al.
Publicado: (2022)

Conformational equilibria and intrinsic affinities define integrin activation
por: Li, Jing, et al.
Publicado: (2017)

Chemokines and the Signaling Modules Regulating Integrin Affinity
por: Montresor, Alessio, et al.
Publicado: (2012)

Identification of osteogenic progenitor cell-targeted peptides that augment bone formation
por: Jiang, Min, et al.
Publicado: (2020)

Integrins and their ligands in rheumatoid arthritis
por: Lowin, Torsten, et al.
Publicado: (2011)

Discovery of Peptidic Ligands against the SARS-CoV-2 Spike Protein and Their Use in the Development of a Highly Sensitive Personal Use Colorimetric COVID-19 Biosensor
por: Yu, Xingjian, et al.
Publicado: (2023)

Site-Specific Albumin-Selective Ligation to Human Serum Albumin under Physiological Conditions
por: Yu, Xingjian, et al.
Publicado: (2022)

Variation in One Residue Associated with the Metal Ion-Dependent Adhesion Site Regulates αIIbβ3 Integrin Ligand Binding Affinity
por: Raborn, Joel, et al.
Publicado: (2013)

Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair
por: Hao, Dake, et al.
Publicado: (2022)

N,N-Dimethylaminopyrene as a fluorescent affinity mass tag for ligand-binding mode analysis
por: Arai, Atsushi, et al.
Publicado: (2020)

Enhancement of crystallization with nucleotide ligands identified by dye-ligand affinity chromatography
por: Kim, Heungbok, et al.
Publicado: (2012)

Tumor Targeting via Integrin Ligands
por: Marelli, Udaya Kiran, et al.
Publicado: (2013)

Artificial Affinity Proteins as Ligands of Immunoglobulins
por: Mouratou, Barbara, et al.
Publicado: (2015)

The molecular basis of talin2’s high affinity toward β1-integrin
por: Yuan, Yaxia, et al.
Publicado: (2017)

Small molecule tyrosine kinase inhibitors modulated blood immune cell counts in patients with oncogene-driven NSCLC
por: Ma, Weijie, et al.
Publicado: (2021)

Structure–Activity Relationship of RGD-Containing Cyclic Octapeptide and αvβ3 Integrin Allows for Rapid Identification of a New Peptide Antagonist
por: Silva, Aaron, et al.
Publicado: (2020)

Identification of integrin drug targets for 17 solid tumor types
por: Arun, Adith S., et al.
Publicado: (2018)

Control cell migration by engineering integrin ligand assembly
por: Hu, Xunwu, et al.
Publicado: (2022)

Neutrophil Integrins and Matrix Ligands and NET Release
por: O’Brien, Xian M., et al.
Publicado: (2016)

Inspirations of Biomimetic Affinity Ligands: A Review
por: Topçu, Aykut Arif, et al.
Publicado: (2022)

Photoswitching Affinity and Mechanism of Multivalent Lectin Ligands
por: Osswald, Uwe, et al.
Publicado: (2022)

Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity
por: Kumar, Vinod, et al.
Publicado: (2014)

Interaction of leukocyte integrins with ligand is necessary but not sufficient for function
Publicado: (1992)

Demonstration of catch bonds between an integrin and its ligand
por: Kong, Fang, et al.
Publicado: (2009)

Beyond the Matrix: The Many Non-ECM Ligands for Integrins
por: LaFoya, Bryce, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_s92847h6tjkj6o95c2s1mm54ob