Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics

One of the major challenges of RNA-based therapeutics is the method for delivery of RNA molecules. In a recent article (Nat Commun 9(1):2359), we described a novel delivery platform for RNA-based drugs using red blood cell extracellular vesicles which can efficiently deliver both small and large RNA...

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Autores principales: Pham, Chanh Tin, Zhang, Xin, Lam, Austin, Le, Minh TN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2018
Materias:
Microreview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558925/
https://www.ncbi.nlm.nih.gov/pubmed/31225493
http://dx.doi.org/10.15698/cst2018.09.155
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author Pham, Chanh Tin
Zhang, Xin
Lam, Austin
Le, Minh TN
author_facet Pham, Chanh Tin
Zhang, Xin
Lam, Austin
Le, Minh TN
author_sort Pham, Chanh Tin
collection PubMed
description One of the major challenges of RNA-based therapeutics is the method for delivery of RNA molecules. In a recent article (Nat Commun 9(1):2359), we described a novel delivery platform for RNA-based drugs using red blood cell extracellular vesicles which can efficiently deliver both small and large RNAs to solid and liquid tumours. Our RBCEVs platform features exceptional merits over conventional RNA delivery methods in biosafety, biocompatibility, efficiency, accessibility, and cost effectiveness.
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spelling pubmed-65589252019-06-20 Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics Pham, Chanh Tin Zhang, Xin Lam, Austin Le, Minh TN Cell Stress Microreview One of the major challenges of RNA-based therapeutics is the method for delivery of RNA molecules. In a recent article (Nat Commun 9(1):2359), we described a novel delivery platform for RNA-based drugs using red blood cell extracellular vesicles which can efficiently deliver both small and large RNAs to solid and liquid tumours. Our RBCEVs platform features exceptional merits over conventional RNA delivery methods in biosafety, biocompatibility, efficiency, accessibility, and cost effectiveness. Shared Science Publishers OG 2018-08-30 /pmc/articles/PMC6558925/ /pubmed/31225493 http://dx.doi.org/10.15698/cst2018.09.155 Text en Copyright: © 2018 Pham et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Microreview
Pham, Chanh Tin
Zhang, Xin
Lam, Austin
Le, Minh TN
Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics
title Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics
title_full Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics
title_fullStr Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics
title_full_unstemmed Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics
title_short Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics
title_sort red blood cell extracellular vesicles as robust carriers of rna-based therapeutics
topic Microreview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558925/
https://www.ncbi.nlm.nih.gov/pubmed/31225493
http://dx.doi.org/10.15698/cst2018.09.155
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