Cytochemical tests to investigate sperm DNA damage: Assessment and review

Male factor infertility has been diagnosed as the cause of infertility in about 20% of infertile couples. Sperm analysis is the most common method for diagnosing infertility in a laboratory. However, approximately 15% of infertile men have a normal sperm analysis. Therefore, the result of a routine...

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Autores principales: Pourmasumi, Soheila, Nazari, Alireza, Fagheirelahee, Niloofar, Sabeti, Parvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559112/
https://www.ncbi.nlm.nih.gov/pubmed/31198709
http://dx.doi.org/10.4103/jfmpc.jfmpc_35_19
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author Pourmasumi, Soheila
Nazari, Alireza
Fagheirelahee, Niloofar
Sabeti, Parvin
author_facet Pourmasumi, Soheila
Nazari, Alireza
Fagheirelahee, Niloofar
Sabeti, Parvin
author_sort Pourmasumi, Soheila
collection PubMed
description Male factor infertility has been diagnosed as the cause of infertility in about 20% of infertile couples. Sperm analysis is the most common method for diagnosing infertility in a laboratory. However, approximately 15% of infertile men have a normal sperm analysis. Therefore, the result of a routine sperm analysis often cannot be a definitive diagnosis for male factor infertility. Also, approximately 8% of infertile men with normal sperm parameters have high levels of abnormal sperm DNA. This indicates the role of the integrity of sperm DNA in male infertility. Here, we review the current tests available to evaluate the sperm DNA integrity along with their benefits and limitations.
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spelling pubmed-65591122019-06-13 Cytochemical tests to investigate sperm DNA damage: Assessment and review Pourmasumi, Soheila Nazari, Alireza Fagheirelahee, Niloofar Sabeti, Parvin J Family Med Prim Care Review Article Male factor infertility has been diagnosed as the cause of infertility in about 20% of infertile couples. Sperm analysis is the most common method for diagnosing infertility in a laboratory. However, approximately 15% of infertile men have a normal sperm analysis. Therefore, the result of a routine sperm analysis often cannot be a definitive diagnosis for male factor infertility. Also, approximately 8% of infertile men with normal sperm parameters have high levels of abnormal sperm DNA. This indicates the role of the integrity of sperm DNA in male infertility. Here, we review the current tests available to evaluate the sperm DNA integrity along with their benefits and limitations. Wolters Kluwer - Medknow 2019-05 /pmc/articles/PMC6559112/ /pubmed/31198709 http://dx.doi.org/10.4103/jfmpc.jfmpc_35_19 Text en Copyright: © 2019 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Pourmasumi, Soheila
Nazari, Alireza
Fagheirelahee, Niloofar
Sabeti, Parvin
Cytochemical tests to investigate sperm DNA damage: Assessment and review
title Cytochemical tests to investigate sperm DNA damage: Assessment and review
title_full Cytochemical tests to investigate sperm DNA damage: Assessment and review
title_fullStr Cytochemical tests to investigate sperm DNA damage: Assessment and review
title_full_unstemmed Cytochemical tests to investigate sperm DNA damage: Assessment and review
title_short Cytochemical tests to investigate sperm DNA damage: Assessment and review
title_sort cytochemical tests to investigate sperm dna damage: assessment and review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559112/
https://www.ncbi.nlm.nih.gov/pubmed/31198709
http://dx.doi.org/10.4103/jfmpc.jfmpc_35_19
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