miRNA-302e attenuates inflammation in infantile pneumonia though the RelA/BRD4/NF-κB signaling pathway

In the present study, the main focus was investigating the role of microRNA (miRNA)-302e in infantile pneumonia (IP) and exploring the potential protective mechanisms. Briefly, the expression of miRNA-302e was reduced in a mouse model of IP. In addition, the administration of anti-miRNA-302e increas...

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Autores principales: Li, Shaoxia, Cui, Wenwen, Song, Qing, Zhou, Yufei, Li, Jingtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559299/
https://www.ncbi.nlm.nih.gov/pubmed/31115487
http://dx.doi.org/10.3892/ijmm.2019.4194
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author Li, Shaoxia
Cui, Wenwen
Song, Qing
Zhou, Yufei
Li, Jingtao
author_facet Li, Shaoxia
Cui, Wenwen
Song, Qing
Zhou, Yufei
Li, Jingtao
author_sort Li, Shaoxia
collection PubMed
description In the present study, the main focus was investigating the role of microRNA (miRNA)-302e in infantile pneumonia (IP) and exploring the potential protective mechanisms. Briefly, the expression of miRNA-302e was reduced in a mouse model of IP. In addition, the administration of anti-miRNA-302e increased inflammation and induced the protein expression of RelA, bromodomain-containing protein 4 (BRD4) and nuclear factor (NF)-κB in the in vitro model of IP. In contrast, over-expression of miRNA-302e reduced inflammation and suppressed the protein expression of RelA, BRD4 and NF-κB in an in vitro model of IP. Small interfering (si)-RelA attenuated the effects of miRNA-302e on inflammation in an in vitro model of IP. Consistently, si-BRD4 or si-NF-κB attenuated the effects of miRNA-302e on inflammation in an in vitro model of IP. Taken together, the results of the present study demonstrated that miRNA-302e attenuated inflammation in IP through the RelA/ BRD4/ NF-κB signaling pathway.
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spelling pubmed-65592992019-06-12 miRNA-302e attenuates inflammation in infantile pneumonia though the RelA/BRD4/NF-κB signaling pathway Li, Shaoxia Cui, Wenwen Song, Qing Zhou, Yufei Li, Jingtao Int J Mol Med Articles In the present study, the main focus was investigating the role of microRNA (miRNA)-302e in infantile pneumonia (IP) and exploring the potential protective mechanisms. Briefly, the expression of miRNA-302e was reduced in a mouse model of IP. In addition, the administration of anti-miRNA-302e increased inflammation and induced the protein expression of RelA, bromodomain-containing protein 4 (BRD4) and nuclear factor (NF)-κB in the in vitro model of IP. In contrast, over-expression of miRNA-302e reduced inflammation and suppressed the protein expression of RelA, BRD4 and NF-κB in an in vitro model of IP. Small interfering (si)-RelA attenuated the effects of miRNA-302e on inflammation in an in vitro model of IP. Consistently, si-BRD4 or si-NF-κB attenuated the effects of miRNA-302e on inflammation in an in vitro model of IP. Taken together, the results of the present study demonstrated that miRNA-302e attenuated inflammation in IP through the RelA/ BRD4/ NF-κB signaling pathway. D.A. Spandidos 2019-07 2019-05-10 /pmc/articles/PMC6559299/ /pubmed/31115487 http://dx.doi.org/10.3892/ijmm.2019.4194 Text en Copyright: © Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Li, Shaoxia
Cui, Wenwen
Song, Qing
Zhou, Yufei
Li, Jingtao
miRNA-302e attenuates inflammation in infantile pneumonia though the RelA/BRD4/NF-κB signaling pathway
title miRNA-302e attenuates inflammation in infantile pneumonia though the RelA/BRD4/NF-κB signaling pathway
title_full miRNA-302e attenuates inflammation in infantile pneumonia though the RelA/BRD4/NF-κB signaling pathway
title_fullStr miRNA-302e attenuates inflammation in infantile pneumonia though the RelA/BRD4/NF-κB signaling pathway
title_full_unstemmed miRNA-302e attenuates inflammation in infantile pneumonia though the RelA/BRD4/NF-κB signaling pathway
title_short miRNA-302e attenuates inflammation in infantile pneumonia though the RelA/BRD4/NF-κB signaling pathway
title_sort mirna-302e attenuates inflammation in infantile pneumonia though the rela/brd4/nf-κb signaling pathway
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559299/
https://www.ncbi.nlm.nih.gov/pubmed/31115487
http://dx.doi.org/10.3892/ijmm.2019.4194
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