The molecular mechanisms underlying BCR/ABL degradation in chronic myeloid leukemia cells promoted by Beclin1-mediated autophagy

Background: The development of drug resistance and the persistence of leukemia stem cells are major obstacles for the use of tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML). The induction of autophagic death in tumor cells represents a new route for leukemia trea...

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Detalles Bibliográficos
Autores principales: Huang, Xianbo, Li, Ying, Shou, Lihong, Li, Li, Chen, Zhenzhen, Ye, Xiujin, Qian, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559765/
https://www.ncbi.nlm.nih.gov/pubmed/31239774
http://dx.doi.org/10.2147/CMAR.S202442

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