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Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila
Integration of stimuli of different modalities is an important but incompletely understood process during decision making. Here, we show that Drosophila are capable of integrating mechanosensory and chemosensory information of choice options when deciding where to deposit their eggs. Specifically, f...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559806/ https://www.ncbi.nlm.nih.gov/pubmed/31184585 http://dx.doi.org/10.7554/eLife.46165 |
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author | Wu, Shun-Fan Ja, Ya-Long Zhang, Yi-jie Yang, Chung-Hui |
author_facet | Wu, Shun-Fan Ja, Ya-Long Zhang, Yi-jie Yang, Chung-Hui |
author_sort | Wu, Shun-Fan |
collection | PubMed |
description | Integration of stimuli of different modalities is an important but incompletely understood process during decision making. Here, we show that Drosophila are capable of integrating mechanosensory and chemosensory information of choice options when deciding where to deposit their eggs. Specifically, females switch from preferring the softer option for egg-laying when both options are sugar free to being indifferent between them when both contain sucrose. Such sucrose-induced indifference between options of different hardness requires functional sweet neurons, and, curiously, the Transmembrane Channel-like (TMC)-expressing mechanosensitive neurons that have been previously shown to promote discrimination of substrate hardness during feeding. Further, axons of sweet neurons directly contact axons of TMC-expressing neurons in the brain and stimulation of sweet neurons increases Ca(2+) influx into axons of TMC-expressing neurons. These results uncover one mechanism by which Drosophila integrate taste and tactile information when deciding where to deposit their eggs and reveal that TMC-expressing neurons play opposing roles in hardness discrimination in two different decisions. |
format | Online Article Text |
id | pubmed-6559806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-65598062019-06-13 Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila Wu, Shun-Fan Ja, Ya-Long Zhang, Yi-jie Yang, Chung-Hui eLife Neuroscience Integration of stimuli of different modalities is an important but incompletely understood process during decision making. Here, we show that Drosophila are capable of integrating mechanosensory and chemosensory information of choice options when deciding where to deposit their eggs. Specifically, females switch from preferring the softer option for egg-laying when both options are sugar free to being indifferent between them when both contain sucrose. Such sucrose-induced indifference between options of different hardness requires functional sweet neurons, and, curiously, the Transmembrane Channel-like (TMC)-expressing mechanosensitive neurons that have been previously shown to promote discrimination of substrate hardness during feeding. Further, axons of sweet neurons directly contact axons of TMC-expressing neurons in the brain and stimulation of sweet neurons increases Ca(2+) influx into axons of TMC-expressing neurons. These results uncover one mechanism by which Drosophila integrate taste and tactile information when deciding where to deposit their eggs and reveal that TMC-expressing neurons play opposing roles in hardness discrimination in two different decisions. eLife Sciences Publications, Ltd 2019-06-11 /pmc/articles/PMC6559806/ /pubmed/31184585 http://dx.doi.org/10.7554/eLife.46165 Text en © 2019, Wu et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Wu, Shun-Fan Ja, Ya-Long Zhang, Yi-jie Yang, Chung-Hui Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila |
title | Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila |
title_full | Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila |
title_fullStr | Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila |
title_full_unstemmed | Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila |
title_short | Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila |
title_sort | sweet neurons inhibit texture discrimination by signaling tmc-expressing mechanosensitive neurons in drosophila |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559806/ https://www.ncbi.nlm.nih.gov/pubmed/31184585 http://dx.doi.org/10.7554/eLife.46165 |
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