LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8(+) T cell tumor-infiltration impairing anti-PD1 therapy

Cancer response to immunotherapy depends on the infiltration of CD8(+) T cells and the presence of tumor-associated macrophages within tumors. Still, little is known about the determinants of these factors. We show that LIF assumes a crucial role in the regulation of CD8(+) T cell tumor infiltration...

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Detalles Bibliográficos
Autores principales: Pascual-García, Mónica, Bonfill-Teixidor, Ester, Planas-Rigol, Ester, Rubio-Perez, Carlota, Iurlaro, Raffaella, Arias, Alexandra, Cuartas, Isabel, Sala-Hojman, Ada, Escudero, Laura, Martínez-Ricarte, Francisco, Huber-Ruano, Isabel, Nuciforo, Paolo, Pedrosa, Leire, Marques, Carolina, Braña, Irene, Garralda, Elena, Vieito, María, Squatrito, Massimo, Pineda, Estela, Graus, Francesc, Espejo, Carmen, Sahuquillo, Juan, Tabernero, Josep, Seoane, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559950/
https://www.ncbi.nlm.nih.gov/pubmed/31186412
http://dx.doi.org/10.1038/s41467-019-10369-9

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