The relevance of microRNA in post-infarction left ventricular remodelling and heart failure

Myocardial infarction and post-infarction left ventricular remodelling involve a high risk of morbidity and mortality. For this reason, ongoing research is being conducted in order to learn the mechanisms of unfavourable left ventricular remodelling following a myocardial infarction. New biomarkers...

Descripción completa

Detalles Bibliográficos
Autores principales: Dutka, Mieczysław, Bobiński, Rafał, Korbecki, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560007/
https://www.ncbi.nlm.nih.gov/pubmed/30710255
http://dx.doi.org/10.1007/s10741-019-09770-9
_version_ 1783425881463586816
author Dutka, Mieczysław
Bobiński, Rafał
Korbecki, Jan
author_facet Dutka, Mieczysław
Bobiński, Rafał
Korbecki, Jan
author_sort Dutka, Mieczysław
collection PubMed
description Myocardial infarction and post-infarction left ventricular remodelling involve a high risk of morbidity and mortality. For this reason, ongoing research is being conducted in order to learn the mechanisms of unfavourable left ventricular remodelling following a myocardial infarction. New biomarkers are also being sought that would allow for early identification of patients with a high risk of post-infarction remodelling and dysfunction of the left ventricle. In recent years, there has been ever more experimental data that confirms the significance of microRNA in cardiovascular diseases. It has been confirmed that microRNAs are stable in systemic circulation, and can be directly measured in patients’ blood. It has been found that significant changes occur in the concentrations of various types of microRNA in myocardial infarction and heart failure patients. Various types of microRNA are also currently being intensively researched in terms of their usefulness as markers of cardiomyocyte necrosis, and predictors of the post-infarction heart failure development. This paper is a summary of the current knowledge on the significance of microRNA in post-infarction left ventricular remodelling and heart failure.
format Online
Article
Text
id pubmed-6560007
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-65600072019-06-26 The relevance of microRNA in post-infarction left ventricular remodelling and heart failure Dutka, Mieczysław Bobiński, Rafał Korbecki, Jan Heart Fail Rev Article Myocardial infarction and post-infarction left ventricular remodelling involve a high risk of morbidity and mortality. For this reason, ongoing research is being conducted in order to learn the mechanisms of unfavourable left ventricular remodelling following a myocardial infarction. New biomarkers are also being sought that would allow for early identification of patients with a high risk of post-infarction remodelling and dysfunction of the left ventricle. In recent years, there has been ever more experimental data that confirms the significance of microRNA in cardiovascular diseases. It has been confirmed that microRNAs are stable in systemic circulation, and can be directly measured in patients’ blood. It has been found that significant changes occur in the concentrations of various types of microRNA in myocardial infarction and heart failure patients. Various types of microRNA are also currently being intensively researched in terms of their usefulness as markers of cardiomyocyte necrosis, and predictors of the post-infarction heart failure development. This paper is a summary of the current knowledge on the significance of microRNA in post-infarction left ventricular remodelling and heart failure. Springer US 2019-02-02 2019 /pmc/articles/PMC6560007/ /pubmed/30710255 http://dx.doi.org/10.1007/s10741-019-09770-9 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Dutka, Mieczysław
Bobiński, Rafał
Korbecki, Jan
The relevance of microRNA in post-infarction left ventricular remodelling and heart failure
title The relevance of microRNA in post-infarction left ventricular remodelling and heart failure
title_full The relevance of microRNA in post-infarction left ventricular remodelling and heart failure
title_fullStr The relevance of microRNA in post-infarction left ventricular remodelling and heart failure
title_full_unstemmed The relevance of microRNA in post-infarction left ventricular remodelling and heart failure
title_short The relevance of microRNA in post-infarction left ventricular remodelling and heart failure
title_sort relevance of microrna in post-infarction left ventricular remodelling and heart failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560007/
https://www.ncbi.nlm.nih.gov/pubmed/30710255
http://dx.doi.org/10.1007/s10741-019-09770-9
work_keys_str_mv AT dutkamieczysław therelevanceofmicrornainpostinfarctionleftventricularremodellingandheartfailure
AT bobinskirafał therelevanceofmicrornainpostinfarctionleftventricularremodellingandheartfailure
AT korbeckijan therelevanceofmicrornainpostinfarctionleftventricularremodellingandheartfailure
AT dutkamieczysław relevanceofmicrornainpostinfarctionleftventricularremodellingandheartfailure
AT bobinskirafał relevanceofmicrornainpostinfarctionleftventricularremodellingandheartfailure
AT korbeckijan relevanceofmicrornainpostinfarctionleftventricularremodellingandheartfailure

Ejemplares similares