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Non-neutral evolution of H3.3-encoding genes occurs without alterations in protein sequence

Histone H3.3 is a developmentally essential variant encoded by two independent genes in human (H3F3A and H3F3B). While this two-gene arrangement is evolutionarily conserved, its origins and function remain unknown. Phylogenetics, synteny and gene structure analyses of H3.3 genes from 32 metazoan gen...

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Detalles Bibliográficos
Autores principales:	Muhire, Brejnev M., Booker, Matthew A., Tolstorukov, Michael Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560044/ https://www.ncbi.nlm.nih.gov/pubmed/31186448 http://dx.doi.org/10.1038/s41598-019-44800-4

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