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National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis

BACKGROUND: Low birthweight (LBW) of less than 2500 g is an important marker of maternal and fetal health, predicting mortality, stunting, and adult-onset chronic conditions. Global nutrition targets set at the World Health Assembly in 2012 include an ambitious 30% reduction in LBW prevalence betwee...

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Autores principales: Blencowe, Hannah, Krasevec, Julia, de Onis, Mercedes, Black, Robert E, An, Xiaoyi, Stevens, Gretchen A, Borghi, Elaine, Hayashi, Chika, Estevez, Diana, Cegolon, Luca, Shiekh, Suhail, Ponce Hardy, Victoria, Lawn, Joy E, Cousens, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560046/
https://www.ncbi.nlm.nih.gov/pubmed/31103470
http://dx.doi.org/10.1016/S2214-109X(18)30565-5
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author Blencowe, Hannah
Krasevec, Julia
de Onis, Mercedes
Black, Robert E
An, Xiaoyi
Stevens, Gretchen A
Borghi, Elaine
Hayashi, Chika
Estevez, Diana
Cegolon, Luca
Shiekh, Suhail
Ponce Hardy, Victoria
Lawn, Joy E
Cousens, Simon
author_facet Blencowe, Hannah
Krasevec, Julia
de Onis, Mercedes
Black, Robert E
An, Xiaoyi
Stevens, Gretchen A
Borghi, Elaine
Hayashi, Chika
Estevez, Diana
Cegolon, Luca
Shiekh, Suhail
Ponce Hardy, Victoria
Lawn, Joy E
Cousens, Simon
author_sort Blencowe, Hannah
collection PubMed
description BACKGROUND: Low birthweight (LBW) of less than 2500 g is an important marker of maternal and fetal health, predicting mortality, stunting, and adult-onset chronic conditions. Global nutrition targets set at the World Health Assembly in 2012 include an ambitious 30% reduction in LBW prevalence between 2012 and 2025. Estimates to track progress towards this target are lacking; with this analysis, we aim to assist in setting a baseline against which to assess progress towards the achievement of the World Health Assembly targets. METHODS: We sought to identify all available LBW input data for livebirths for the years 2000–16. We considered population-based national or nationally representative datasets for inclusion if they contained information on birthweight or LBW prevalence for livebirths. A new method for survey adjustment was developed and used. For 57 countries with higher quality time-series data, we smoothed country-reported trends in birthweight data by use of B-spline regression. For all other countries, we estimated LBW prevalence and trends by use of a restricted maximum likelihood approach with country-level random effects. Uncertainty ranges were obtained through bootstrapping. Results were summed at the regional and worldwide level. FINDINGS: We collated 1447 country-years of birthweight data (281 million births) for 148 countries of 195 UN member states (47 countries had no data meeting inclusion criteria). The estimated worldwide LBW prevalence in 2015 was 14·6% (uncertainty range [UR] 12·4–17·1) compared with 17·5% (14·1–21·3) in 2000 (average annual reduction rate [AARR] 1·23%). In 2015, an estimated 20·5 million (UR 17·4–24·0 million) livebirths were LBW, 91% from low-and-middle income countries, mainly southern Asia (48%) and sub-Saharan Africa (24%). INTERPRETATION: Although these estimates suggest some progress in reducing LBW between 2000 and 2015, achieving the 2·74% AARR required between 2012 and 2025 to meet the global nutrition target will require more than doubling progress, involving both improved measurement and programme investments to address the causes of LBW throughout the lifecycle. FUNDING: Bill & Melinda Gates Foundation, The Children's Investment Fund Foundation, United Nations Children's Fund (UNICEF), and WHO.
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spelling pubmed-65600462019-06-17 National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis Blencowe, Hannah Krasevec, Julia de Onis, Mercedes Black, Robert E An, Xiaoyi Stevens, Gretchen A Borghi, Elaine Hayashi, Chika Estevez, Diana Cegolon, Luca Shiekh, Suhail Ponce Hardy, Victoria Lawn, Joy E Cousens, Simon Lancet Glob Health Article BACKGROUND: Low birthweight (LBW) of less than 2500 g is an important marker of maternal and fetal health, predicting mortality, stunting, and adult-onset chronic conditions. Global nutrition targets set at the World Health Assembly in 2012 include an ambitious 30% reduction in LBW prevalence between 2012 and 2025. Estimates to track progress towards this target are lacking; with this analysis, we aim to assist in setting a baseline against which to assess progress towards the achievement of the World Health Assembly targets. METHODS: We sought to identify all available LBW input data for livebirths for the years 2000–16. We considered population-based national or nationally representative datasets for inclusion if they contained information on birthweight or LBW prevalence for livebirths. A new method for survey adjustment was developed and used. For 57 countries with higher quality time-series data, we smoothed country-reported trends in birthweight data by use of B-spline regression. For all other countries, we estimated LBW prevalence and trends by use of a restricted maximum likelihood approach with country-level random effects. Uncertainty ranges were obtained through bootstrapping. Results were summed at the regional and worldwide level. FINDINGS: We collated 1447 country-years of birthweight data (281 million births) for 148 countries of 195 UN member states (47 countries had no data meeting inclusion criteria). The estimated worldwide LBW prevalence in 2015 was 14·6% (uncertainty range [UR] 12·4–17·1) compared with 17·5% (14·1–21·3) in 2000 (average annual reduction rate [AARR] 1·23%). In 2015, an estimated 20·5 million (UR 17·4–24·0 million) livebirths were LBW, 91% from low-and-middle income countries, mainly southern Asia (48%) and sub-Saharan Africa (24%). INTERPRETATION: Although these estimates suggest some progress in reducing LBW between 2000 and 2015, achieving the 2·74% AARR required between 2012 and 2025 to meet the global nutrition target will require more than doubling progress, involving both improved measurement and programme investments to address the causes of LBW throughout the lifecycle. FUNDING: Bill & Melinda Gates Foundation, The Children's Investment Fund Foundation, United Nations Children's Fund (UNICEF), and WHO. Elsevier Ltd 2019-05-15 /pmc/articles/PMC6560046/ /pubmed/31103470 http://dx.doi.org/10.1016/S2214-109X(18)30565-5 Text en © 2019 UNICEF and World Health Organization. Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Blencowe, Hannah
Krasevec, Julia
de Onis, Mercedes
Black, Robert E
An, Xiaoyi
Stevens, Gretchen A
Borghi, Elaine
Hayashi, Chika
Estevez, Diana
Cegolon, Luca
Shiekh, Suhail
Ponce Hardy, Victoria
Lawn, Joy E
Cousens, Simon
National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis
title National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis
title_full National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis
title_fullStr National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis
title_full_unstemmed National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis
title_short National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis
title_sort national, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560046/
https://www.ncbi.nlm.nih.gov/pubmed/31103470
http://dx.doi.org/10.1016/S2214-109X(18)30565-5
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