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DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration

Iron homeostasis is an essential prerequisite for metabolic and neurological functions throughout the healthy human life, with a dynamic interplay between intracellular and systemic iron metabolism. The development of different neurodegenerative diseases is associated with alterations of the intrace...

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Autores principales: Ingrassia, Rosaria, Garavaglia, Barbara, Memo, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560079/
https://www.ncbi.nlm.nih.gov/pubmed/31231185
http://dx.doi.org/10.3389/fnins.2019.00575
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author Ingrassia, Rosaria
Garavaglia, Barbara
Memo, Maurizio
author_facet Ingrassia, Rosaria
Garavaglia, Barbara
Memo, Maurizio
author_sort Ingrassia, Rosaria
collection PubMed
description Iron homeostasis is an essential prerequisite for metabolic and neurological functions throughout the healthy human life, with a dynamic interplay between intracellular and systemic iron metabolism. The development of different neurodegenerative diseases is associated with alterations of the intracellular transport of iron and heavy metals, principally mediated by Divalent Metal Transporter 1 (DMT1), responsible for Non-Transferrin Bound Iron transport (NTBI). In addition, DMT1 regulation and its compartmentalization in specific brain regions play important roles during aging. This review highlights the contribution of DMT1 to the physiological exchange and distribution of body iron and heavy metals during aging and neurodegenerative diseases. DMT1 also mediates the crosstalk between central nervous system and peripheral tissues, by systemic diffusion through the Blood Brain Barrier (BBB), with the involvement of peripheral iron homeostasis in association with inflammation. In conclusion, a survey about the role of DMT1 and iron will illustrate the complex panel of interrelationship with aging, neurodegeneration and neuroinflammation.
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spelling pubmed-65600792019-06-21 DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration Ingrassia, Rosaria Garavaglia, Barbara Memo, Maurizio Front Neurosci Neuroscience Iron homeostasis is an essential prerequisite for metabolic and neurological functions throughout the healthy human life, with a dynamic interplay between intracellular and systemic iron metabolism. The development of different neurodegenerative diseases is associated with alterations of the intracellular transport of iron and heavy metals, principally mediated by Divalent Metal Transporter 1 (DMT1), responsible for Non-Transferrin Bound Iron transport (NTBI). In addition, DMT1 regulation and its compartmentalization in specific brain regions play important roles during aging. This review highlights the contribution of DMT1 to the physiological exchange and distribution of body iron and heavy metals during aging and neurodegenerative diseases. DMT1 also mediates the crosstalk between central nervous system and peripheral tissues, by systemic diffusion through the Blood Brain Barrier (BBB), with the involvement of peripheral iron homeostasis in association with inflammation. In conclusion, a survey about the role of DMT1 and iron will illustrate the complex panel of interrelationship with aging, neurodegeneration and neuroinflammation. Frontiers Media S.A. 2019-06-05 /pmc/articles/PMC6560079/ /pubmed/31231185 http://dx.doi.org/10.3389/fnins.2019.00575 Text en Copyright © 2019 Ingrassia, Garavaglia and Memo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ingrassia, Rosaria
Garavaglia, Barbara
Memo, Maurizio
DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration
title DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration
title_full DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration
title_fullStr DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration
title_full_unstemmed DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration
title_short DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration
title_sort dmt1 expression and iron levels at the crossroads between aging and neurodegeneration
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560079/
https://www.ncbi.nlm.nih.gov/pubmed/31231185
http://dx.doi.org/10.3389/fnins.2019.00575
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