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Association of antidepressants with brain morphology in early stages of psychosis: an imaging genomics approach
Depressive symptoms in subjects at Clinical High Risk for Psychosis (CHR-P) or at first-episode psychosis (FEP) are often treated with antidepressants. Our cross-sectional study investigated whether brain morphology is altered by antidepressant medication. High-resolution T(1)-weighted structural MR...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560086/ https://www.ncbi.nlm.nih.gov/pubmed/31186482 http://dx.doi.org/10.1038/s41598-019-44903-y |
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author | Bykowsky, Oleg Harrisberger, Fabienne Schmidt, André Smieskova, Renata Hauke, Daniel J. Egloff, Laura Riecher-Rössler, Anita Fusar-Poli, Paolo Huber, Christian G. Lang, Undine E. Andreou, Christina Borgwardt, Stefan |
author_facet | Bykowsky, Oleg Harrisberger, Fabienne Schmidt, André Smieskova, Renata Hauke, Daniel J. Egloff, Laura Riecher-Rössler, Anita Fusar-Poli, Paolo Huber, Christian G. Lang, Undine E. Andreou, Christina Borgwardt, Stefan |
author_sort | Bykowsky, Oleg |
collection | PubMed |
description | Depressive symptoms in subjects at Clinical High Risk for Psychosis (CHR-P) or at first-episode psychosis (FEP) are often treated with antidepressants. Our cross-sectional study investigated whether brain morphology is altered by antidepressant medication. High-resolution T(1)-weighted structural MRI scans of 33 CHR-P and FEP subjects treated with antidepressants, 102 CHR-P and FEP individuals without antidepressant treatment and 55 controls, were automatically segmented using Freesurfer 6.0. Linear mixed-effects modelling was applied to assess the differences in subcortical volume, surface area and cortical thickness in treated, non-treated and healthy subjects, taking into account converted dosages of antidepressants. Increasing antidepressant dose was associated with larger volume of the pallidum and the putamen, and larger surface of the left inferior temporal gyrus. In a pilot subsample of separately studied subjects of known genomic risk loci, we found that in the right postcentral gyrus, the left paracentral lobule and the precentral gyrus antidepressant dose-associated surface increase depended on polygenic schizophrenia-related-risk score. As the reported regions are linked to the symptoms of psychosis, our findings reflect the possible beneficial effects of antidepressant treatment on an emerging psychosis. |
format | Online Article Text |
id | pubmed-6560086 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65600862019-06-19 Association of antidepressants with brain morphology in early stages of psychosis: an imaging genomics approach Bykowsky, Oleg Harrisberger, Fabienne Schmidt, André Smieskova, Renata Hauke, Daniel J. Egloff, Laura Riecher-Rössler, Anita Fusar-Poli, Paolo Huber, Christian G. Lang, Undine E. Andreou, Christina Borgwardt, Stefan Sci Rep Article Depressive symptoms in subjects at Clinical High Risk for Psychosis (CHR-P) or at first-episode psychosis (FEP) are often treated with antidepressants. Our cross-sectional study investigated whether brain morphology is altered by antidepressant medication. High-resolution T(1)-weighted structural MRI scans of 33 CHR-P and FEP subjects treated with antidepressants, 102 CHR-P and FEP individuals without antidepressant treatment and 55 controls, were automatically segmented using Freesurfer 6.0. Linear mixed-effects modelling was applied to assess the differences in subcortical volume, surface area and cortical thickness in treated, non-treated and healthy subjects, taking into account converted dosages of antidepressants. Increasing antidepressant dose was associated with larger volume of the pallidum and the putamen, and larger surface of the left inferior temporal gyrus. In a pilot subsample of separately studied subjects of known genomic risk loci, we found that in the right postcentral gyrus, the left paracentral lobule and the precentral gyrus antidepressant dose-associated surface increase depended on polygenic schizophrenia-related-risk score. As the reported regions are linked to the symptoms of psychosis, our findings reflect the possible beneficial effects of antidepressant treatment on an emerging psychosis. Nature Publishing Group UK 2019-06-11 /pmc/articles/PMC6560086/ /pubmed/31186482 http://dx.doi.org/10.1038/s41598-019-44903-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bykowsky, Oleg Harrisberger, Fabienne Schmidt, André Smieskova, Renata Hauke, Daniel J. Egloff, Laura Riecher-Rössler, Anita Fusar-Poli, Paolo Huber, Christian G. Lang, Undine E. Andreou, Christina Borgwardt, Stefan Association of antidepressants with brain morphology in early stages of psychosis: an imaging genomics approach |
title | Association of antidepressants with brain morphology in early stages of psychosis: an imaging genomics approach |
title_full | Association of antidepressants with brain morphology in early stages of psychosis: an imaging genomics approach |
title_fullStr | Association of antidepressants with brain morphology in early stages of psychosis: an imaging genomics approach |
title_full_unstemmed | Association of antidepressants with brain morphology in early stages of psychosis: an imaging genomics approach |
title_short | Association of antidepressants with brain morphology in early stages of psychosis: an imaging genomics approach |
title_sort | association of antidepressants with brain morphology in early stages of psychosis: an imaging genomics approach |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560086/ https://www.ncbi.nlm.nih.gov/pubmed/31186482 http://dx.doi.org/10.1038/s41598-019-44903-y |
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