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Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice

AIMS/HYPOTHESIS: The aim of this study was to elucidate the impact of 3′-phosphoinositide-dependent protein kinase-1 (PDPK1) in vascular endothelial cells on the maintenance of pancreatic beta cell mass and function. METHODS: Male vascular endothelial cell-specific Pdpk1-knockout mice (Tie2(+/−)/Pdp...

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Detalles Bibliográficos
Autores principales:	Obata, Atsushi, Kimura, Tomohiko, Obata, Yoshiyuki, Shimoda, Masashi, Kinoshita, Tomoe, Kohara, Kenji, Okauchi, Seizo, Hirukawa, Hidenori, Kamei, Shinji, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560212/ https://www.ncbi.nlm.nih.gov/pubmed/31055616 http://dx.doi.org/10.1007/s00125-019-4878-1

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