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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

Body fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369...

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Autores principales:	Justice, Anne E, Karaderi, Tugce, Highland, Heather M, Young, Kristin L, Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L, Fine, Rebecca S, Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W, Locke, Adam E, Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie CY, Heard-Costa, Nancy L, Feitosa, Mary F, Manning, Alisa K, Willems, Sara M, Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S, Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A, Bork-Jensen, Jette, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Broer, Linda, Burt, Amber A, Butterworth, Adam S, Caulfield, Mark J, Cesana, Giancarlo, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Collins, Francis S, Cook, James P, Cox, Amanda J, Crosslin, David S, Danesh, John, de Bakker, Paul IW, de Denus, Simon, de Mutsert, Renée, Dedoussis, George, Demerath, Ellen W, Dennis, Joe G, Denny, Josh C, Di Angelantonio, Emanuele, Dörr, Marcus, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M, Easton, Douglas F, Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C, Fornage, Myriam, Fox, Caroline S, Franks, Paul W, Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Girotto, Giorgia, Gorski, Mathias, Grallert, Harald, Grarup, Niels, Grove, Megan L, Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T, Hayward, Caroline, Heid, Iris M, Holmen, Oddgeir L, Hovingh, G Kees, Howson, Joanna MM, Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M Arfan, Ingelsson, Erik, Jackson, Anne U, Jarvik, Gail P, Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M, Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon LR, Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S, Kovacs, Peter, Krämer, Bernhard K, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A, Lamparter, David, Lange, Leslie A, Langenberg, Claudia, Larson, Eric B, Lee, Nanette R, Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E, Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J, Luan, Jian’an, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas GD, McCarthy, Mark I, Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O, Morgan, Anna, Morris, Andrew P, Müller-Nurasyid, Martina, Munroe, Patricia B, Narisu, Narisu, Nelson, Christopher P, Neville, Matt, Ntalla, Ioanna, O’Connell, Jeffrey R, Owen, Katharine R, Pedersen, Oluf, Peloso, Gina M, Pennell, Craig E, Perola, Markus, Perry, James A, Perry, John RB, Pers, Tune H, Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T, Rasheed, Asif, Raulerson, Chelsea K, Rauramaa, Rainer, Reilly, Dermot F, Reiner, Alex P, Ridker, Paul M, Rivas, Manuel A, Robertson, Neil R, Robino, Antonietta, Rudan, Igor, Ruth, Katherine S, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J, Schreiner, Pamela J, Schulze, Matthias B, Scott, Robert A, Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J, Small, Kerrin S, Smith, Blair H, Smith, Jennifer A, Southam, Lorraine, Spector, Timothy D, Speliotes, Elizabeth K, Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E, Strauch, Konstantin, Stringham, Heather M, Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin MA, Tardif, Jean-Claude, Taylor, Kent D, Teumer, Alexander, Thompson, Deborah J, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H, Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G, Uusitupa, Matti, van Duijn, Cornelia M, Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F, Vuckovic, Dragana, Wagenknecht, Lynne E, Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A, Wang, Shuai, Wareham, Nicholas J, Warren, Helen R, Waterworth, Dawn M, Wessel, Jennifer, White, Harvey D, Willer, Cristen J, Wilson, James G, Wood, Andrew R, Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M, Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M Carola, Rivadeneira, Fernando, Borecki, Ingrid B, Pospisilik, J. Andrew, Deloukas, Panos, Frayling, Timothy M, Lettre, Guillaume, Mohlke, Karen L, Rotter, Jerome I, Kutalik, Zoltán, Hirschhorn, Joel N, Cupples, L Adrienne, Loos, Ruth JF, North, Kari E, Lindgren, Cecilia M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560635/ https://www.ncbi.nlm.nih.gov/pubmed/30778226 http://dx.doi.org/10.1038/s41588-018-0334-2

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author	Justice, Anne E Karaderi, Tugce Highland, Heather M Young, Kristin L Graff, Mariaelisa Lu, Yingchang Turcot, Valérie Auer, Paul L Fine, Rebecca S Guo, Xiuqing Schurmann, Claudia Lempradl, Adelheid Marouli, Eirini Mahajan, Anubha Winkler, Thomas W Locke, Adam E Medina-Gomez, Carolina Esko, Tõnu Vedantam, Sailaja Giri, Ayush Lo, Ken Sin Alfred, Tamuno Mudgal, Poorva Ng, Maggie CY Heard-Costa, Nancy L Feitosa, Mary F Manning, Alisa K Willems, Sara M Sivapalaratnam, Suthesh Abecasis, Goncalo Alam, Dewan S Allison, Matthew Amouyel, Philippe Arzumanyan, Zorayr Balkau, Beverley Bastarache, Lisa Bergmann, Sven Bielak, Lawrence F Blüher, Matthias Boehnke, Michael Boeing, Heiner Boerwinkle, Eric Böger, Carsten A Bork-Jensen, Jette Bottinger, Erwin P Bowden, Donald W Brandslund, Ivan Broer, Linda Burt, Amber A Butterworth, Adam S Caulfield, Mark J Cesana, Giancarlo Chambers, John C Chasman, Daniel I Chen, Yii-Der Ida Chowdhury, Rajiv Christensen, Cramer Chu, Audrey Y Collins, Francis S Cook, James P Cox, Amanda J Crosslin, David S Danesh, John de Bakker, Paul IW de Denus, Simon de Mutsert, Renée Dedoussis, George Demerath, Ellen W Dennis, Joe G Denny, Josh C Di Angelantonio, Emanuele Dörr, Marcus Drenos, Fotios Dubé, Marie-Pierre Dunning, Alison M Easton, Douglas F Elliott, Paul Evangelou, Evangelos Farmaki, Aliki-Eleni Feng, Shuang Ferrannini, Ele Ferrieres, Jean Florez, Jose C Fornage, Myriam Fox, Caroline S Franks, Paul W Friedrich, Nele Gan, Wei Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Girotto, Giorgia Gorski, Mathias Grallert, Harald Grarup, Niels Grove, Megan L Gustafsson, Stefan Haessler, Jeff Hansen, Torben Hattersley, Andrew T Hayward, Caroline Heid, Iris M Holmen, Oddgeir L Hovingh, G Kees Howson, Joanna MM Hu, Yao Hung, Yi-Jen Hveem, Kristian Ikram, M Arfan Ingelsson, Erik Jackson, Anne U Jarvik, Gail P Jia, Yucheng Jørgensen, Torben Jousilahti, Pekka Justesen, Johanne M Kahali, Bratati Karaleftheri, Maria Kardia, Sharon LR Karpe, Fredrik Kee, Frank Kitajima, Hidetoshi Komulainen, Pirjo Kooner, Jaspal S Kovacs, Peter Krämer, Bernhard K Kuulasmaa, Kari Kuusisto, Johanna Laakso, Markku Lakka, Timo A Lamparter, David Lange, Leslie A Langenberg, Claudia Larson, Eric B Lee, Nanette R Lee, Wen-Jane Lehtimäki, Terho Lewis, Cora E Li, Huaixing Li, Jin Li-Gao, Ruifang Lin, Li-An Lin, Xu Lind, Lars Lindström, Jaana Linneberg, Allan Liu, Ching-Ti Liu, Dajiang J Luan, Jian’an Lyytikäinen, Leo-Pekka MacGregor, Stuart Mägi, Reedik Männistö, Satu Marenne, Gaëlle Marten, Jonathan Masca, Nicholas GD McCarthy, Mark I Meidtner, Karina Mihailov, Evelin Moilanen, Leena Moitry, Marie Mook-Kanamori, Dennis O Morgan, Anna Morris, Andrew P Müller-Nurasyid, Martina Munroe, Patricia B Narisu, Narisu Nelson, Christopher P Neville, Matt Ntalla, Ioanna O’Connell, Jeffrey R Owen, Katharine R Pedersen, Oluf Peloso, Gina M Pennell, Craig E Perola, Markus Perry, James A Perry, John RB Pers, Tune H Ewing, Ailith Polasek, Ozren Raitakari, Olli T Rasheed, Asif Raulerson, Chelsea K Rauramaa, Rainer Reilly, Dermot F Reiner, Alex P Ridker, Paul M Rivas, Manuel A Robertson, Neil R Robino, Antonietta Rudan, Igor Ruth, Katherine S Saleheen, Danish Salomaa, Veikko Samani, Nilesh J Schreiner, Pamela J Schulze, Matthias B Scott, Robert A Segura-Lepe, Marcelo Sim, Xueling Slater, Andrew J Small, Kerrin S Smith, Blair H Smith, Jennifer A Southam, Lorraine Spector, Timothy D Speliotes, Elizabeth K Stefansson, Kari Steinthorsdottir, Valgerdur Stirrups, Kathleen E Strauch, Konstantin Stringham, Heather M Stumvoll, Michael Sun, Liang Surendran, Praveen Swart, Karin MA Tardif, Jean-Claude Taylor, Kent D Teumer, Alexander Thompson, Deborah J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Thuesen, Betina H Tönjes, Anke Torres, Mina Tsafantakis, Emmanouil Tuomilehto, Jaakko Uitterlinden, André G Uusitupa, Matti van Duijn, Cornelia M Vanhala, Mauno Varma, Rohit Vermeulen, Sita H Vestergaard, Henrik Vitart, Veronique Vogt, Thomas F Vuckovic, Dragana Wagenknecht, Lynne E Walker, Mark Wallentin, Lars Wang, Feijie Wang, Carol A Wang, Shuai Wareham, Nicholas J Warren, Helen R Waterworth, Dawn M Wessel, Jennifer White, Harvey D Willer, Cristen J Wilson, James G Wood, Andrew R Wu, Ying Yaghootkar, Hanieh Yao, Jie Yerges-Armstrong, Laura M Young, Robin Zeggini, Eleftheria Zhan, Xiaowei Zhang, Weihua Zhao, Jing Hua Zhao, Wei Zheng, He Zhou, Wei Zillikens, M Carola Rivadeneira, Fernando Borecki, Ingrid B Pospisilik, J. Andrew Deloukas, Panos Frayling, Timothy M Lettre, Guillaume Mohlke, Karen L Rotter, Jerome I Kutalik, Zoltán Hirschhorn, Joel N Cupples, L Adrienne Loos, Ruth JF North, Kari E Lindgren, Cecilia M
author_facet	Justice, Anne E Karaderi, Tugce Highland, Heather M Young, Kristin L Graff, Mariaelisa Lu, Yingchang Turcot, Valérie Auer, Paul L Fine, Rebecca S Guo, Xiuqing Schurmann, Claudia Lempradl, Adelheid Marouli, Eirini Mahajan, Anubha Winkler, Thomas W Locke, Adam E Medina-Gomez, Carolina Esko, Tõnu Vedantam, Sailaja Giri, Ayush Lo, Ken Sin Alfred, Tamuno Mudgal, Poorva Ng, Maggie CY Heard-Costa, Nancy L Feitosa, Mary F Manning, Alisa K Willems, Sara M Sivapalaratnam, Suthesh Abecasis, Goncalo Alam, Dewan S Allison, Matthew Amouyel, Philippe Arzumanyan, Zorayr Balkau, Beverley Bastarache, Lisa Bergmann, Sven Bielak, Lawrence F Blüher, Matthias Boehnke, Michael Boeing, Heiner Boerwinkle, Eric Böger, Carsten A Bork-Jensen, Jette Bottinger, Erwin P Bowden, Donald W Brandslund, Ivan Broer, Linda Burt, Amber A Butterworth, Adam S Caulfield, Mark J Cesana, Giancarlo Chambers, John C Chasman, Daniel I Chen, Yii-Der Ida Chowdhury, Rajiv Christensen, Cramer Chu, Audrey Y Collins, Francis S Cook, James P Cox, Amanda J Crosslin, David S Danesh, John de Bakker, Paul IW de Denus, Simon de Mutsert, Renée Dedoussis, George Demerath, Ellen W Dennis, Joe G Denny, Josh C Di Angelantonio, Emanuele Dörr, Marcus Drenos, Fotios Dubé, Marie-Pierre Dunning, Alison M Easton, Douglas F Elliott, Paul Evangelou, Evangelos Farmaki, Aliki-Eleni Feng, Shuang Ferrannini, Ele Ferrieres, Jean Florez, Jose C Fornage, Myriam Fox, Caroline S Franks, Paul W Friedrich, Nele Gan, Wei Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Girotto, Giorgia Gorski, Mathias Grallert, Harald Grarup, Niels Grove, Megan L Gustafsson, Stefan Haessler, Jeff Hansen, Torben Hattersley, Andrew T Hayward, Caroline Heid, Iris M Holmen, Oddgeir L Hovingh, G Kees Howson, Joanna MM Hu, Yao Hung, Yi-Jen Hveem, Kristian Ikram, M Arfan Ingelsson, Erik Jackson, Anne U Jarvik, Gail P Jia, Yucheng Jørgensen, Torben Jousilahti, Pekka Justesen, Johanne M Kahali, Bratati Karaleftheri, Maria Kardia, Sharon LR Karpe, Fredrik Kee, Frank Kitajima, Hidetoshi Komulainen, Pirjo Kooner, Jaspal S Kovacs, Peter Krämer, Bernhard K Kuulasmaa, Kari Kuusisto, Johanna Laakso, Markku Lakka, Timo A Lamparter, David Lange, Leslie A Langenberg, Claudia Larson, Eric B Lee, Nanette R Lee, Wen-Jane Lehtimäki, Terho Lewis, Cora E Li, Huaixing Li, Jin Li-Gao, Ruifang Lin, Li-An Lin, Xu Lind, Lars Lindström, Jaana Linneberg, Allan Liu, Ching-Ti Liu, Dajiang J Luan, Jian’an Lyytikäinen, Leo-Pekka MacGregor, Stuart Mägi, Reedik Männistö, Satu Marenne, Gaëlle Marten, Jonathan Masca, Nicholas GD McCarthy, Mark I Meidtner, Karina Mihailov, Evelin Moilanen, Leena Moitry, Marie Mook-Kanamori, Dennis O Morgan, Anna Morris, Andrew P Müller-Nurasyid, Martina Munroe, Patricia B Narisu, Narisu Nelson, Christopher P Neville, Matt Ntalla, Ioanna O’Connell, Jeffrey R Owen, Katharine R Pedersen, Oluf Peloso, Gina M Pennell, Craig E Perola, Markus Perry, James A Perry, John RB Pers, Tune H Ewing, Ailith Polasek, Ozren Raitakari, Olli T Rasheed, Asif Raulerson, Chelsea K Rauramaa, Rainer Reilly, Dermot F Reiner, Alex P Ridker, Paul M Rivas, Manuel A Robertson, Neil R Robino, Antonietta Rudan, Igor Ruth, Katherine S Saleheen, Danish Salomaa, Veikko Samani, Nilesh J Schreiner, Pamela J Schulze, Matthias B Scott, Robert A Segura-Lepe, Marcelo Sim, Xueling Slater, Andrew J Small, Kerrin S Smith, Blair H Smith, Jennifer A Southam, Lorraine Spector, Timothy D Speliotes, Elizabeth K Stefansson, Kari Steinthorsdottir, Valgerdur Stirrups, Kathleen E Strauch, Konstantin Stringham, Heather M Stumvoll, Michael Sun, Liang Surendran, Praveen Swart, Karin MA Tardif, Jean-Claude Taylor, Kent D Teumer, Alexander Thompson, Deborah J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Thuesen, Betina H Tönjes, Anke Torres, Mina Tsafantakis, Emmanouil Tuomilehto, Jaakko Uitterlinden, André G Uusitupa, Matti van Duijn, Cornelia M Vanhala, Mauno Varma, Rohit Vermeulen, Sita H Vestergaard, Henrik Vitart, Veronique Vogt, Thomas F Vuckovic, Dragana Wagenknecht, Lynne E Walker, Mark Wallentin, Lars Wang, Feijie Wang, Carol A Wang, Shuai Wareham, Nicholas J Warren, Helen R Waterworth, Dawn M Wessel, Jennifer White, Harvey D Willer, Cristen J Wilson, James G Wood, Andrew R Wu, Ying Yaghootkar, Hanieh Yao, Jie Yerges-Armstrong, Laura M Young, Robin Zeggini, Eleftheria Zhan, Xiaowei Zhang, Weihua Zhao, Jing Hua Zhao, Wei Zheng, He Zhou, Wei Zillikens, M Carola Rivadeneira, Fernando Borecki, Ingrid B Pospisilik, J. Andrew Deloukas, Panos Frayling, Timothy M Lettre, Guillaume Mohlke, Karen L Rotter, Jerome I Kutalik, Zoltán Hirschhorn, Joel N Cupples, L Adrienne Loos, Ruth JF North, Kari E Lindgren, Cecilia M
author_sort	Justice, Anne E
collection	PubMed
description	Body fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥ 5%) and 9 low frequency or rare (MAF < 5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology, and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.
format	Online Article Text
id	pubmed-6560635
institution	National Center for Biotechnology Information
language	English
publishDate	2019
record_format	MEDLINE/PubMed
spelling	pubmed-65606352019-08-18 PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION Justice, Anne E Karaderi, Tugce Highland, Heather M Young, Kristin L Graff, Mariaelisa Lu, Yingchang Turcot, Valérie Auer, Paul L Fine, Rebecca S Guo, Xiuqing Schurmann, Claudia Lempradl, Adelheid Marouli, Eirini Mahajan, Anubha Winkler, Thomas W Locke, Adam E Medina-Gomez, Carolina Esko, Tõnu Vedantam, Sailaja Giri, Ayush Lo, Ken Sin Alfred, Tamuno Mudgal, Poorva Ng, Maggie CY Heard-Costa, Nancy L Feitosa, Mary F Manning, Alisa K Willems, Sara M Sivapalaratnam, Suthesh Abecasis, Goncalo Alam, Dewan S Allison, Matthew Amouyel, Philippe Arzumanyan, Zorayr Balkau, Beverley Bastarache, Lisa Bergmann, Sven Bielak, Lawrence F Blüher, Matthias Boehnke, Michael Boeing, Heiner Boerwinkle, Eric Böger, Carsten A Bork-Jensen, Jette Bottinger, Erwin P Bowden, Donald W Brandslund, Ivan Broer, Linda Burt, Amber A Butterworth, Adam S Caulfield, Mark J Cesana, Giancarlo Chambers, John C Chasman, Daniel I Chen, Yii-Der Ida Chowdhury, Rajiv Christensen, Cramer Chu, Audrey Y Collins, Francis S Cook, James P Cox, Amanda J Crosslin, David S Danesh, John de Bakker, Paul IW de Denus, Simon de Mutsert, Renée Dedoussis, George Demerath, Ellen W Dennis, Joe G Denny, Josh C Di Angelantonio, Emanuele Dörr, Marcus Drenos, Fotios Dubé, Marie-Pierre Dunning, Alison M Easton, Douglas F Elliott, Paul Evangelou, Evangelos Farmaki, Aliki-Eleni Feng, Shuang Ferrannini, Ele Ferrieres, Jean Florez, Jose C Fornage, Myriam Fox, Caroline S Franks, Paul W Friedrich, Nele Gan, Wei Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Girotto, Giorgia Gorski, Mathias Grallert, Harald Grarup, Niels Grove, Megan L Gustafsson, Stefan Haessler, Jeff Hansen, Torben Hattersley, Andrew T Hayward, Caroline Heid, Iris M Holmen, Oddgeir L Hovingh, G Kees Howson, Joanna MM Hu, Yao Hung, Yi-Jen Hveem, Kristian Ikram, M Arfan Ingelsson, Erik Jackson, Anne U Jarvik, Gail P Jia, Yucheng Jørgensen, Torben Jousilahti, Pekka Justesen, Johanne M Kahali, Bratati Karaleftheri, Maria Kardia, Sharon LR Karpe, Fredrik Kee, Frank Kitajima, Hidetoshi Komulainen, Pirjo Kooner, Jaspal S Kovacs, Peter Krämer, Bernhard K Kuulasmaa, Kari Kuusisto, Johanna Laakso, Markku Lakka, Timo A Lamparter, David Lange, Leslie A Langenberg, Claudia Larson, Eric B Lee, Nanette R Lee, Wen-Jane Lehtimäki, Terho Lewis, Cora E Li, Huaixing Li, Jin Li-Gao, Ruifang Lin, Li-An Lin, Xu Lind, Lars Lindström, Jaana Linneberg, Allan Liu, Ching-Ti Liu, Dajiang J Luan, Jian’an Lyytikäinen, Leo-Pekka MacGregor, Stuart Mägi, Reedik Männistö, Satu Marenne, Gaëlle Marten, Jonathan Masca, Nicholas GD McCarthy, Mark I Meidtner, Karina Mihailov, Evelin Moilanen, Leena Moitry, Marie Mook-Kanamori, Dennis O Morgan, Anna Morris, Andrew P Müller-Nurasyid, Martina Munroe, Patricia B Narisu, Narisu Nelson, Christopher P Neville, Matt Ntalla, Ioanna O’Connell, Jeffrey R Owen, Katharine R Pedersen, Oluf Peloso, Gina M Pennell, Craig E Perola, Markus Perry, James A Perry, John RB Pers, Tune H Ewing, Ailith Polasek, Ozren Raitakari, Olli T Rasheed, Asif Raulerson, Chelsea K Rauramaa, Rainer Reilly, Dermot F Reiner, Alex P Ridker, Paul M Rivas, Manuel A Robertson, Neil R Robino, Antonietta Rudan, Igor Ruth, Katherine S Saleheen, Danish Salomaa, Veikko Samani, Nilesh J Schreiner, Pamela J Schulze, Matthias B Scott, Robert A Segura-Lepe, Marcelo Sim, Xueling Slater, Andrew J Small, Kerrin S Smith, Blair H Smith, Jennifer A Southam, Lorraine Spector, Timothy D Speliotes, Elizabeth K Stefansson, Kari Steinthorsdottir, Valgerdur Stirrups, Kathleen E Strauch, Konstantin Stringham, Heather M Stumvoll, Michael Sun, Liang Surendran, Praveen Swart, Karin MA Tardif, Jean-Claude Taylor, Kent D Teumer, Alexander Thompson, Deborah J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Thuesen, Betina H Tönjes, Anke Torres, Mina Tsafantakis, Emmanouil Tuomilehto, Jaakko Uitterlinden, André G Uusitupa, Matti van Duijn, Cornelia M Vanhala, Mauno Varma, Rohit Vermeulen, Sita H Vestergaard, Henrik Vitart, Veronique Vogt, Thomas F Vuckovic, Dragana Wagenknecht, Lynne E Walker, Mark Wallentin, Lars Wang, Feijie Wang, Carol A Wang, Shuai Wareham, Nicholas J Warren, Helen R Waterworth, Dawn M Wessel, Jennifer White, Harvey D Willer, Cristen J Wilson, James G Wood, Andrew R Wu, Ying Yaghootkar, Hanieh Yao, Jie Yerges-Armstrong, Laura M Young, Robin Zeggini, Eleftheria Zhan, Xiaowei Zhang, Weihua Zhao, Jing Hua Zhao, Wei Zheng, He Zhou, Wei Zillikens, M Carola Rivadeneira, Fernando Borecki, Ingrid B Pospisilik, J. Andrew Deloukas, Panos Frayling, Timothy M Lettre, Guillaume Mohlke, Karen L Rotter, Jerome I Kutalik, Zoltán Hirschhorn, Joel N Cupples, L Adrienne Loos, Ruth JF North, Kari E Lindgren, Cecilia M Nat Genet Article Body fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥ 5%) and 9 low frequency or rare (MAF < 5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology, and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants. 2019-02-18 2019-03 /pmc/articles/PMC6560635/ /pubmed/30778226 http://dx.doi.org/10.1038/s41588-018-0334-2 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle	Article Justice, Anne E Karaderi, Tugce Highland, Heather M Young, Kristin L Graff, Mariaelisa Lu, Yingchang Turcot, Valérie Auer, Paul L Fine, Rebecca S Guo, Xiuqing Schurmann, Claudia Lempradl, Adelheid Marouli, Eirini Mahajan, Anubha Winkler, Thomas W Locke, Adam E Medina-Gomez, Carolina Esko, Tõnu Vedantam, Sailaja Giri, Ayush Lo, Ken Sin Alfred, Tamuno Mudgal, Poorva Ng, Maggie CY Heard-Costa, Nancy L Feitosa, Mary F Manning, Alisa K Willems, Sara M Sivapalaratnam, Suthesh Abecasis, Goncalo Alam, Dewan S Allison, Matthew Amouyel, Philippe Arzumanyan, Zorayr Balkau, Beverley Bastarache, Lisa Bergmann, Sven Bielak, Lawrence F Blüher, Matthias Boehnke, Michael Boeing, Heiner Boerwinkle, Eric Böger, Carsten A Bork-Jensen, Jette Bottinger, Erwin P Bowden, Donald W Brandslund, Ivan Broer, Linda Burt, Amber A Butterworth, Adam S Caulfield, Mark J Cesana, Giancarlo Chambers, John C Chasman, Daniel I Chen, Yii-Der Ida Chowdhury, Rajiv Christensen, Cramer Chu, Audrey Y Collins, Francis S Cook, James P Cox, Amanda J Crosslin, David S Danesh, John de Bakker, Paul IW de Denus, Simon de Mutsert, Renée Dedoussis, George Demerath, Ellen W Dennis, Joe G Denny, Josh C Di Angelantonio, Emanuele Dörr, Marcus Drenos, Fotios Dubé, Marie-Pierre Dunning, Alison M Easton, Douglas F Elliott, Paul Evangelou, Evangelos Farmaki, Aliki-Eleni Feng, Shuang Ferrannini, Ele Ferrieres, Jean Florez, Jose C Fornage, Myriam Fox, Caroline S Franks, Paul W Friedrich, Nele Gan, Wei Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Girotto, Giorgia Gorski, Mathias Grallert, Harald Grarup, Niels Grove, Megan L Gustafsson, Stefan Haessler, Jeff Hansen, Torben Hattersley, Andrew T Hayward, Caroline Heid, Iris M Holmen, Oddgeir L Hovingh, G Kees Howson, Joanna MM Hu, Yao Hung, Yi-Jen Hveem, Kristian Ikram, M Arfan Ingelsson, Erik Jackson, Anne U Jarvik, Gail P Jia, Yucheng Jørgensen, Torben Jousilahti, Pekka Justesen, Johanne M Kahali, Bratati Karaleftheri, Maria Kardia, Sharon LR Karpe, Fredrik Kee, Frank Kitajima, Hidetoshi Komulainen, Pirjo Kooner, Jaspal S Kovacs, Peter Krämer, Bernhard K Kuulasmaa, Kari Kuusisto, Johanna Laakso, Markku Lakka, Timo A Lamparter, David Lange, Leslie A Langenberg, Claudia Larson, Eric B Lee, Nanette R Lee, Wen-Jane Lehtimäki, Terho Lewis, Cora E Li, Huaixing Li, Jin Li-Gao, Ruifang Lin, Li-An Lin, Xu Lind, Lars Lindström, Jaana Linneberg, Allan Liu, Ching-Ti Liu, Dajiang J Luan, Jian’an Lyytikäinen, Leo-Pekka MacGregor, Stuart Mägi, Reedik Männistö, Satu Marenne, Gaëlle Marten, Jonathan Masca, Nicholas GD McCarthy, Mark I Meidtner, Karina Mihailov, Evelin Moilanen, Leena Moitry, Marie Mook-Kanamori, Dennis O Morgan, Anna Morris, Andrew P Müller-Nurasyid, Martina Munroe, Patricia B Narisu, Narisu Nelson, Christopher P Neville, Matt Ntalla, Ioanna O’Connell, Jeffrey R Owen, Katharine R Pedersen, Oluf Peloso, Gina M Pennell, Craig E Perola, Markus Perry, James A Perry, John RB Pers, Tune H Ewing, Ailith Polasek, Ozren Raitakari, Olli T Rasheed, Asif Raulerson, Chelsea K Rauramaa, Rainer Reilly, Dermot F Reiner, Alex P Ridker, Paul M Rivas, Manuel A Robertson, Neil R Robino, Antonietta Rudan, Igor Ruth, Katherine S Saleheen, Danish Salomaa, Veikko Samani, Nilesh J Schreiner, Pamela J Schulze, Matthias B Scott, Robert A Segura-Lepe, Marcelo Sim, Xueling Slater, Andrew J Small, Kerrin S Smith, Blair H Smith, Jennifer A Southam, Lorraine Spector, Timothy D Speliotes, Elizabeth K Stefansson, Kari Steinthorsdottir, Valgerdur Stirrups, Kathleen E Strauch, Konstantin Stringham, Heather M Stumvoll, Michael Sun, Liang Surendran, Praveen Swart, Karin MA Tardif, Jean-Claude Taylor, Kent D Teumer, Alexander Thompson, Deborah J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Thuesen, Betina H Tönjes, Anke Torres, Mina Tsafantakis, Emmanouil Tuomilehto, Jaakko Uitterlinden, André G Uusitupa, Matti van Duijn, Cornelia M Vanhala, Mauno Varma, Rohit Vermeulen, Sita H Vestergaard, Henrik Vitart, Veronique Vogt, Thomas F Vuckovic, Dragana Wagenknecht, Lynne E Walker, Mark Wallentin, Lars Wang, Feijie Wang, Carol A Wang, Shuai Wareham, Nicholas J Warren, Helen R Waterworth, Dawn M Wessel, Jennifer White, Harvey D Willer, Cristen J Wilson, James G Wood, Andrew R Wu, Ying Yaghootkar, Hanieh Yao, Jie Yerges-Armstrong, Laura M Young, Robin Zeggini, Eleftheria Zhan, Xiaowei Zhang, Weihua Zhao, Jing Hua Zhao, Wei Zheng, He Zhou, Wei Zillikens, M Carola Rivadeneira, Fernando Borecki, Ingrid B Pospisilik, J. Andrew Deloukas, Panos Frayling, Timothy M Lettre, Guillaume Mohlke, Karen L Rotter, Jerome I Kutalik, Zoltán Hirschhorn, Joel N Cupples, L Adrienne Loos, Ruth JF North, Kari E Lindgren, Cecilia M PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION
title	PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION
title_full	PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION
title_fullStr	PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION
title_full_unstemmed	PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION
title_short	PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION
title_sort	protein-coding variants implicate novel genes related to lipid homeostasis contributing to body fat distribution
topic	Article
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560635/ https://www.ncbi.nlm.nih.gov/pubmed/30778226 http://dx.doi.org/10.1038/s41588-018-0334-2
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proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT perstuneh proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT ewingailith proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT polasekozren proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT raitakariollit proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT rasheedasif proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT raulersonchelseak proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT rauramaarainer proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT reillydermotf proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT reineralexp proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT ridkerpaulm proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT rivasmanuela proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT robertsonneilr proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT robinoantonietta proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT rudanigor proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT ruthkatherines proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT saleheendanish proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT salomaaveikko proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT samaninileshj proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT schreinerpamelaj proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT schulzematthiasb proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT scottroberta proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT seguralepemarcelo proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT simxueling proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT slaterandrewj proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT smallkerrins proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT smithblairh proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT smithjennifera proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT southamlorraine proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT spectortimothyd proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT spelioteselizabethk proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT stefanssonkari proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT steinthorsdottirvalgerdur proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT stirrupskathleene proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT strauchkonstantin proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT stringhamheatherm proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT stumvollmichael proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT sunliang proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT surendranpraveen proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT swartkarinma proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT tardifjeanclaude proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT taylorkentd proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT teumeralexander proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT thompsondeborahj proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT thorleifssongudmar proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT thorsteinsdottirunnur proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT thuesenbetinah proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT tonjesanke proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT torresmina proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT tsafantakisemmanouil proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT tuomilehtojaakko proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT uitterlindenandreg proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT uusitupamatti proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT vanduijncorneliam proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT vanhalamauno proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT varmarohit proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT vermeulensitah proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT vestergaardhenrik proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT vitartveronique proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT vogtthomasf proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT vuckovicdragana proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT wagenknechtlynnee proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT walkermark proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT wallentinlars proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT wangfeijie proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT wangcarola proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT wangshuai proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT warehamnicholasj proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT warrenhelenr proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT waterworthdawnm proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT wesseljennifer proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT whiteharveyd proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT willercristenj proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT wilsonjamesg proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT woodandrewr proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT wuying proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT yaghootkarhanieh proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT yaojie proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT yergesarmstronglauram proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT youngrobin proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT zegginieleftheria proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT zhanxiaowei proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT zhangweihua proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT zhaojinghua proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT zhaowei proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT zhenghe proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT zhouwei proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT zillikensmcarola proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT rivadeneirafernando proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT boreckiingridb proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT pospisilikjandrew proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT deloukaspanos proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT fraylingtimothym proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT lettreguillaume proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT mohlkekarenl proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT rotterjeromei proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT kutalikzoltan proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT hirschhornjoeln proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT cupplesladrienne proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT loosruthjf proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT northkarie proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution AT lindgrenceciliam proteincodingvariantsimplicatenovelgenesrelatedtolipidhomeostasiscontributingtobodyfatdistribution

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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