Multiple levels of the unknown in microbiome research

Metagenomics allows exploration of aspects of a microbial community that were inaccessible by cultivation-based approaches targeting single microbes. Many new microbial taxa and genes have been discovered using metagenomics, but different kinds of “unknowns” still remain in a microbiome experiment....

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Detalles Bibliográficos
Autores principales: Thomas, Andrew Maltez, Segata, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560723/
https://www.ncbi.nlm.nih.gov/pubmed/31189463
http://dx.doi.org/10.1186/s12915-019-0667-z
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author Thomas, Andrew Maltez
Segata, Nicola
author_facet Thomas, Andrew Maltez
Segata, Nicola
author_sort Thomas, Andrew Maltez
collection PubMed
description Metagenomics allows exploration of aspects of a microbial community that were inaccessible by cultivation-based approaches targeting single microbes. Many new microbial taxa and genes have been discovered using metagenomics, but different kinds of “unknowns” still remain in a microbiome experiment. We discuss here whether and how it is possible to deal with them.
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spelling pubmed-65607232019-06-14 Multiple levels of the unknown in microbiome research Thomas, Andrew Maltez Segata, Nicola BMC Biol Comment Metagenomics allows exploration of aspects of a microbial community that were inaccessible by cultivation-based approaches targeting single microbes. Many new microbial taxa and genes have been discovered using metagenomics, but different kinds of “unknowns” still remain in a microbiome experiment. We discuss here whether and how it is possible to deal with them. BioMed Central 2019-06-12 /pmc/articles/PMC6560723/ /pubmed/31189463 http://dx.doi.org/10.1186/s12915-019-0667-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Thomas, Andrew Maltez
Segata, Nicola
Multiple levels of the unknown in microbiome research
title Multiple levels of the unknown in microbiome research
title_full Multiple levels of the unknown in microbiome research
title_fullStr Multiple levels of the unknown in microbiome research
title_full_unstemmed Multiple levels of the unknown in microbiome research
title_short Multiple levels of the unknown in microbiome research
title_sort multiple levels of the unknown in microbiome research
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560723/
https://www.ncbi.nlm.nih.gov/pubmed/31189463
http://dx.doi.org/10.1186/s12915-019-0667-z
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