TREM-1-dependent M1 macrophage polarization restores intestinal epithelium damaged by DSS-induced colitis by activating IL-22-producing innate lymphoid cells

BACKGROUND: Triggering receptor expressed on myeloid cells-1 (TREM-1) is highly expressed on macrophages in inflamed intestines and reportedly promotes inflammatory bowel disease (IBD) by augmenting pro-inflammatory responses. To study the mechanism mediated by TREM-1 on macrophages, we generated an...

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Detalles Bibliográficos
Autores principales: Yang, Fu-Chen, Chiu, Po-Yuan, Chen, Yun, Mak, Tak W., Chen, Nien-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560756/
https://www.ncbi.nlm.nih.gov/pubmed/31189465
http://dx.doi.org/10.1186/s12929-019-0539-4

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