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Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question
Rhesus hemolytic disease of the newborn is rarely found after the implementation of anti-D immunoglobulin prophylaxis. However, it may lead to cholestasis, elevated liver transaminases, iron overload and late hyporegenerative anemia when it occurs. Etiology of this type of anemia is not defined yet...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The African Field Epidemiology Network
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560958/ https://www.ncbi.nlm.nih.gov/pubmed/31223410 http://dx.doi.org/10.11604/pamj.2019.32.120.17757 |
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author | Alaqeel, Aqeel Abdullah |
author_facet | Alaqeel, Aqeel Abdullah |
author_sort | Alaqeel, Aqeel Abdullah |
collection | PubMed |
description | Rhesus hemolytic disease of the newborn is rarely found after the implementation of anti-D immunoglobulin prophylaxis. However, it may lead to cholestasis, elevated liver transaminases, iron overload and late hyporegenerative anemia when it occurs. Etiology of this type of anemia is not defined yet and treatment is controversial. It is typically recognized after two weeks of life which is characterized by low hemoglobin and reticulocyte count. We have reported a case of a neonate with Rh hemolytic disease with late hyporegenerative anemia that was noted at day 18 of life. We treated this anemia by erythropoietin (EPO) 250 U/kg three times per week. Two weeks after initiation of erythropoietin treatment, a stable hemoglobin was noted along with an increased reticulocyte count. The patient required one further blood transfusion in the third week of therapy. Other associated findings were self-limited. A year of follow-up showed an appropriate development for age. |
format | Online Article Text |
id | pubmed-6560958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-65609582019-06-20 Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question Alaqeel, Aqeel Abdullah Pan Afr Med J Case Report Rhesus hemolytic disease of the newborn is rarely found after the implementation of anti-D immunoglobulin prophylaxis. However, it may lead to cholestasis, elevated liver transaminases, iron overload and late hyporegenerative anemia when it occurs. Etiology of this type of anemia is not defined yet and treatment is controversial. It is typically recognized after two weeks of life which is characterized by low hemoglobin and reticulocyte count. We have reported a case of a neonate with Rh hemolytic disease with late hyporegenerative anemia that was noted at day 18 of life. We treated this anemia by erythropoietin (EPO) 250 U/kg three times per week. Two weeks after initiation of erythropoietin treatment, a stable hemoglobin was noted along with an increased reticulocyte count. The patient required one further blood transfusion in the third week of therapy. Other associated findings were self-limited. A year of follow-up showed an appropriate development for age. The African Field Epidemiology Network 2019-03-14 /pmc/articles/PMC6560958/ /pubmed/31223410 http://dx.doi.org/10.11604/pamj.2019.32.120.17757 Text en © Aqeel Abdullah Alaqeel et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Alaqeel, Aqeel Abdullah Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question |
title | Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question |
title_full | Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question |
title_fullStr | Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question |
title_full_unstemmed | Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question |
title_short | Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question |
title_sort | hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560958/ https://www.ncbi.nlm.nih.gov/pubmed/31223410 http://dx.doi.org/10.11604/pamj.2019.32.120.17757 |
work_keys_str_mv | AT alaqeelaqeelabdullah hyporegenerativeanemiaandothercomplicationsofrhesushemolyticdiseasetotreatornottotreatisthequestion |