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Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question

Rhesus hemolytic disease of the newborn is rarely found after the implementation of anti-D immunoglobulin prophylaxis. However, it may lead to cholestasis, elevated liver transaminases, iron overload and late hyporegenerative anemia when it occurs. Etiology of this type of anemia is not defined yet...

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Autor principal: Alaqeel, Aqeel Abdullah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560958/
https://www.ncbi.nlm.nih.gov/pubmed/31223410
http://dx.doi.org/10.11604/pamj.2019.32.120.17757
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author Alaqeel, Aqeel Abdullah
author_facet Alaqeel, Aqeel Abdullah
author_sort Alaqeel, Aqeel Abdullah
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description Rhesus hemolytic disease of the newborn is rarely found after the implementation of anti-D immunoglobulin prophylaxis. However, it may lead to cholestasis, elevated liver transaminases, iron overload and late hyporegenerative anemia when it occurs. Etiology of this type of anemia is not defined yet and treatment is controversial. It is typically recognized after two weeks of life which is characterized by low hemoglobin and reticulocyte count. We have reported a case of a neonate with Rh hemolytic disease with late hyporegenerative anemia that was noted at day 18 of life. We treated this anemia by erythropoietin (EPO) 250 U/kg three times per week. Two weeks after initiation of erythropoietin treatment, a stable hemoglobin was noted along with an increased reticulocyte count. The patient required one further blood transfusion in the third week of therapy. Other associated findings were self-limited. A year of follow-up showed an appropriate development for age.
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spelling pubmed-65609582019-06-20 Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question Alaqeel, Aqeel Abdullah Pan Afr Med J Case Report Rhesus hemolytic disease of the newborn is rarely found after the implementation of anti-D immunoglobulin prophylaxis. However, it may lead to cholestasis, elevated liver transaminases, iron overload and late hyporegenerative anemia when it occurs. Etiology of this type of anemia is not defined yet and treatment is controversial. It is typically recognized after two weeks of life which is characterized by low hemoglobin and reticulocyte count. We have reported a case of a neonate with Rh hemolytic disease with late hyporegenerative anemia that was noted at day 18 of life. We treated this anemia by erythropoietin (EPO) 250 U/kg three times per week. Two weeks after initiation of erythropoietin treatment, a stable hemoglobin was noted along with an increased reticulocyte count. The patient required one further blood transfusion in the third week of therapy. Other associated findings were self-limited. A year of follow-up showed an appropriate development for age. The African Field Epidemiology Network 2019-03-14 /pmc/articles/PMC6560958/ /pubmed/31223410 http://dx.doi.org/10.11604/pamj.2019.32.120.17757 Text en © Aqeel Abdullah Alaqeel et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Alaqeel, Aqeel Abdullah
Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question
title Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question
title_full Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question
title_fullStr Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question
title_full_unstemmed Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question
title_short Hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question
title_sort hyporegenerative anemia and other complications of rhesus hemolytic disease: to treat or not to treat is the question
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560958/
https://www.ncbi.nlm.nih.gov/pubmed/31223410
http://dx.doi.org/10.11604/pamj.2019.32.120.17757
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