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Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity
Vitamin A is a dietary component that is essential for the development of intestinal immunity. Vitamin A is absorbed and converted to its bioactive derivatives retinol and retinoic acid by the intestinal epithelium, yet little is known about how epithelial cells regulate vitamin A-dependent intestin...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561173/ https://www.ncbi.nlm.nih.gov/pubmed/31097581 http://dx.doi.org/10.1073/pnas.1812069116 |
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author | Gattu, Sureka Bang, Ye-Ji Pendse, Mihir Dende, Chaitanya Chara, Andrew L. Harris, Tamia A. Wang, Yuhao Ruhn, Kelly A. Kuang, Zheng Sockanathan, Shanthini Hooper, Lora V. |
author_facet | Gattu, Sureka Bang, Ye-Ji Pendse, Mihir Dende, Chaitanya Chara, Andrew L. Harris, Tamia A. Wang, Yuhao Ruhn, Kelly A. Kuang, Zheng Sockanathan, Shanthini Hooper, Lora V. |
author_sort | Gattu, Sureka |
collection | PubMed |
description | Vitamin A is a dietary component that is essential for the development of intestinal immunity. Vitamin A is absorbed and converted to its bioactive derivatives retinol and retinoic acid by the intestinal epithelium, yet little is known about how epithelial cells regulate vitamin A-dependent intestinal immunity. Here we show that epithelial cell expression of the transcription factor retinoic acid receptor β (RARβ) is essential for vitamin A-dependent intestinal immunity. Epithelial RARβ activated vitamin A-dependent expression of serum amyloid A (SAA) proteins by binding directly to Saa promoters. In accordance with the known role of SAAs in regulating Th17 cell effector function, epithelial RARβ promoted IL-17 production by intestinal Th17 cells. More broadly, epithelial RARβ was required for the development of key vitamin A-dependent adaptive immune responses, including CD4(+) T-cell homing to the intestine and the development of IgA-producing intestinal B cells. Our findings provide insight into how the intestinal epithelium senses dietary vitamin A status to regulate adaptive immunity, and highlight the role of epithelial cells in regulating intestinal immunity in response to diet. |
format | Online Article Text |
id | pubmed-6561173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-65611732019-06-17 Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity Gattu, Sureka Bang, Ye-Ji Pendse, Mihir Dende, Chaitanya Chara, Andrew L. Harris, Tamia A. Wang, Yuhao Ruhn, Kelly A. Kuang, Zheng Sockanathan, Shanthini Hooper, Lora V. Proc Natl Acad Sci U S A Biological Sciences Vitamin A is a dietary component that is essential for the development of intestinal immunity. Vitamin A is absorbed and converted to its bioactive derivatives retinol and retinoic acid by the intestinal epithelium, yet little is known about how epithelial cells regulate vitamin A-dependent intestinal immunity. Here we show that epithelial cell expression of the transcription factor retinoic acid receptor β (RARβ) is essential for vitamin A-dependent intestinal immunity. Epithelial RARβ activated vitamin A-dependent expression of serum amyloid A (SAA) proteins by binding directly to Saa promoters. In accordance with the known role of SAAs in regulating Th17 cell effector function, epithelial RARβ promoted IL-17 production by intestinal Th17 cells. More broadly, epithelial RARβ was required for the development of key vitamin A-dependent adaptive immune responses, including CD4(+) T-cell homing to the intestine and the development of IgA-producing intestinal B cells. Our findings provide insight into how the intestinal epithelium senses dietary vitamin A status to regulate adaptive immunity, and highlight the role of epithelial cells in regulating intestinal immunity in response to diet. National Academy of Sciences 2019-05-28 2019-05-16 /pmc/articles/PMC6561173/ /pubmed/31097581 http://dx.doi.org/10.1073/pnas.1812069116 Text en Copyright © 2019 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Gattu, Sureka Bang, Ye-Ji Pendse, Mihir Dende, Chaitanya Chara, Andrew L. Harris, Tamia A. Wang, Yuhao Ruhn, Kelly A. Kuang, Zheng Sockanathan, Shanthini Hooper, Lora V. Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity |
title | Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity |
title_full | Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity |
title_fullStr | Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity |
title_full_unstemmed | Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity |
title_short | Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity |
title_sort | epithelial retinoic acid receptor β regulates serum amyloid a expression and vitamin a-dependent intestinal immunity |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561173/ https://www.ncbi.nlm.nih.gov/pubmed/31097581 http://dx.doi.org/10.1073/pnas.1812069116 |
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