Cargando…

sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH

Endothelial dysfunction and reduced nitric oxide (NO) signaling are a key element of the pathophysiology of nonalcoholic steatohepatitis (NASH). Stimulators of soluble guanylate cyclase (sGC) enhance NO signaling; have been shown preclinically to reduce inflammation, fibrosis, and steatosis; and thu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hall, Katherine C., Bernier, Sylvie G., Jacobson, Sarah, Liu, Guang, Zhang, Ping Y., Sarno, Renee, Catanzano, Victoria, Currie, Mark G., Masferrer, Jaime L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561202/ https://www.ncbi.nlm.nih.gov/pubmed/31085647 http://dx.doi.org/10.1073/pnas.1821045116

Ejemplares similares

Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease
por: Zimmer, Daniel P., et al.
Publicado: (2020)

IWP-121: a novel sGC stimulator that reduces blood pressure and exhibits anti-fibrotic and anti-inflammatory activities in the Dahl Salt-Sensitive rat model
por: Shea, Courtney, et al.
Publicado: (2015)

SUN-662 Praliciguat, a Clinical-Stage Soluble Guanylate Cyclase Stimulator, Improves Lipid Handling and Insulin Sensitivity in Diet-Induced Obese Mice
por: Schwartzkopf, Chad D, et al.
Publicado: (2020)

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats
por: Banijamali, Ali R., et al.
Publicado: (2020)

Structural insights into sGC
por: Akker, Focco van den, et al.
Publicado: (2009)

Conformational changes involved in sGC activation
por: Marletta, Michael A, et al.
Publicado: (2013)

Molecular aspects of sGC regulation
por: Marletta, Michael A, et al.
Publicado: (2011)

Targeting native and apo-sGC
por: Struthers, Mary, et al.
Publicado: (2013)

sGC redox regulation and asthma
por: Stuehr, Dennis J, et al.
Publicado: (2015)

Concomitant administration of sGC stimulators with common classes of anti-hypertensive agents results in increased efficacy in spontaneously hypertensive rats
por: Germano, Peter, et al.
Publicado: (2015)

New clinical results with sGC stimulators
por: Behr, Jürgen
Publicado: (2011)

Synthesis and evaluation of bifunctional sGC regulators
por: Chrominski, Mikolaj, et al.
Publicado: (2013)

Lack of correlation between sGC subunit expression and sGC activity in cerebral development is due to non-heterodimerizing subunits in vivo
por: Haase, Nadine, et al.
Publicado: (2009)

A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide
por: Wittmann, Christine, et al.
Publicado: (2015)

Synergistic mutations in soluble guanylyl cyclase (sGC) reveal a key role for interfacial regions in the sGC activation mechanism
por: Childers, Kenneth C., et al.
Publicado: (2019)

A molecular view of the regulation of sGC activity
por: Marletta, Michael A, et al.
Publicado: (2009)

Structural insights into sGC activation by different activators
por: van den Akker, Focco, et al.
Publicado: (2011)

Genetic modifiers of hypertension in sGC-deficient mice
por: Buys, Emmanuel
Publicado: (2013)

The clinical development of sGC modulators, riociguat and vericiguat
por: Misselwitz, Frank
Publicado: (2015)

SGLT2 inhibition potentiates the cardiovascular, renal, and metabolic effects of sGC stimulation in hypertensive rats with prolonged exposure to high-fat diet
por: Reverte, Virginia, et al.
Publicado: (2022)

An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension
por: Hanrahan, John P., et al.
Publicado: (2019)

Hepatic Stellate Cell-Immune Interactions in NASH
por: Carter, James K., et al.
Publicado: (2022)

New vitamin B(12) derivatives activates sGC
por: Gryko, Dorota, et al.
Publicado: (2011)

Gemfibrozil as a potential heme-independent sGC activator
por: Sobolevsky, Michael, et al.
Publicado: (2011)

Transcriptional regulation of Hepatic Stellate Cell activation in NASH
por: Marcher, Ann-Britt, et al.
Publicado: (2019)

MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes
por: Ma, Ningning, et al.
Publicado: (2023)

sGC activators and stimulators attenuate ischemia/reperfusion injury of the lung
por: Egemnazarov, Bakytbek, et al.
Publicado: (2009)

Phenotypes of sGC mutant mice in basic conditions, disease and shock
por: Brouckaert, Peter, et al.
Publicado: (2009)

Inhaled nitric oxide: an sGC-dependent IOP lowering agent
por: Lieb, Wolfgang S, et al.
Publicado: (2015)

The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate
por: Wang, Chao, et al.
Publicado: (2016)

Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model
por: Schwartzkopf, Chad D., et al.
Publicado: (2022)

BAY 41-2272 Attenuates CTGF Expression via sGC/cGMP-Independent Pathway in TGFβ1-Activated Hepatic Stellate Cells
por: Chen, Po-Jen, et al.
Publicado: (2020)

The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes
por: Ge, Pei, et al.
Publicado: (2016)

Genetic silencing of sGC β1 in cancer: role of epigenetic regulation
por: Sotolongo, Alex, et al.
Publicado: (2013)

Is Innervation of the Neuromuscular Junction at the Diaphragm Modulated by sGC/cGMP Signaling?
por: Lukáčová, Nadežda, et al.
Publicado: (2020)

sGC Activity and Regulation of Blood Flow in a Zebrafish Model System
por: Vishnolia, Krishan K., et al.
Publicado: (2021)

Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO
por: de la Fuente-Alonso, Andrea, et al.
Publicado: (2021)

sGC Stimulation Saves the Diabetic Heart: Red Blood Cells to the Rescue
por: Papapetropoulos, Andreas, et al.
Publicado: (2023)

Inhaled sGC Modulator Can Lower PH in Patients With COPD Without Deteriorating Oxygenation
por: Saffaran, Sina, et al.
Publicado: (2018)

Looking Into the Crystal Ball: Predicting the Future Challenges of Fibrotic NASH Treatment
por: Alkhouri, Naim, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vp501mdetc6aq0v478qvh8ne0i