Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling

The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone—but with no effect on neurotransmission—while another posits that α-syn attenuates neurotransmitter release by restricting synaptic ves...

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Detalles Bibliográficos
Autores principales: Sun, Jichao, Wang, Lina, Bao, Huan, Premi, Sanjay, Das, Utpal, Chapman, Edwin R., Roy, Subhojit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561242/
https://www.ncbi.nlm.nih.gov/pubmed/31110017
http://dx.doi.org/10.1073/pnas.1903049116
Descripción
Sumario:The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone—but with no effect on neurotransmission—while another posits that α-syn attenuates neurotransmitter release by restricting synaptic vesicle mobilization and recycling. Here, we show that α-syn–VAMP2 interactions are necessary for α-syn–induced synaptic attenuation. Our data connect divergent views and suggest a unified model of α-syn function.

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