Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling

The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone—but with no effect on neurotransmission—while another posits that α-syn attenuates neurotransmitter release by restricting synaptic ves...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Jichao, Wang, Lina, Bao, Huan, Premi, Sanjay, Das, Utpal, Chapman, Edwin R., Roy, Subhojit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561242/
https://www.ncbi.nlm.nih.gov/pubmed/31110017
http://dx.doi.org/10.1073/pnas.1903049116
_version_ 1783426102493970432
author Sun, Jichao
Wang, Lina
Bao, Huan
Premi, Sanjay
Das, Utpal
Chapman, Edwin R.
Roy, Subhojit
author_facet Sun, Jichao
Wang, Lina
Bao, Huan
Premi, Sanjay
Das, Utpal
Chapman, Edwin R.
Roy, Subhojit
author_sort Sun, Jichao
collection PubMed
description The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone—but with no effect on neurotransmission—while another posits that α-syn attenuates neurotransmitter release by restricting synaptic vesicle mobilization and recycling. Here, we show that α-syn–VAMP2 interactions are necessary for α-syn–induced synaptic attenuation. Our data connect divergent views and suggest a unified model of α-syn function.
format Online
Article
Text
id pubmed-6561242
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher National Academy of Sciences
record_format MEDLINE/PubMed
spelling pubmed-65612422019-06-17 Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling Sun, Jichao Wang, Lina Bao, Huan Premi, Sanjay Das, Utpal Chapman, Edwin R. Roy, Subhojit Proc Natl Acad Sci U S A Biological Sciences The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone—but with no effect on neurotransmission—while another posits that α-syn attenuates neurotransmitter release by restricting synaptic vesicle mobilization and recycling. Here, we show that α-syn–VAMP2 interactions are necessary for α-syn–induced synaptic attenuation. Our data connect divergent views and suggest a unified model of α-syn function. National Academy of Sciences 2019-06-04 2019-05-20 /pmc/articles/PMC6561242/ /pubmed/31110017 http://dx.doi.org/10.1073/pnas.1903049116 Text en Copyright © 2019 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Sun, Jichao
Wang, Lina
Bao, Huan
Premi, Sanjay
Das, Utpal
Chapman, Edwin R.
Roy, Subhojit
Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
title Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
title_full Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
title_fullStr Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
title_full_unstemmed Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
title_short Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
title_sort functional cooperation of α-synuclein and vamp2 in synaptic vesicle recycling
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561242/
https://www.ncbi.nlm.nih.gov/pubmed/31110017
http://dx.doi.org/10.1073/pnas.1903049116
work_keys_str_mv AT sunjichao functionalcooperationofasynucleinandvamp2insynapticvesiclerecycling
AT wanglina functionalcooperationofasynucleinandvamp2insynapticvesiclerecycling
AT baohuan functionalcooperationofasynucleinandvamp2insynapticvesiclerecycling
AT premisanjay functionalcooperationofasynucleinandvamp2insynapticvesiclerecycling
AT dasutpal functionalcooperationofasynucleinandvamp2insynapticvesiclerecycling
AT chapmanedwinr functionalcooperationofasynucleinandvamp2insynapticvesiclerecycling
AT roysubhojit functionalcooperationofasynucleinandvamp2insynapticvesiclerecycling

Ejemplares similares