Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk

Aging and psychosocial stress are associated with increased inflammation and disease risk, but the underlying molecular mechanisms are unclear. Because both aging and stress are also associated with lasting epigenetic changes, a plausible hypothesis is that stress along the lifespan could confer dis...

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Detalles Bibliográficos
Autores principales: Zannas, Anthony S., Jia, Meiwen, Hafner, Kathrin, Baumert, Jens, Wiechmann, Tobias, Pape, Julius C., Arloth, Janine, Ködel, Maik, Martinelli, Silvia, Roitman, Maria, Röh, Simone, Haehle, Andreas, Emeny, Rebecca T., Iurato, Stella, Carrillo-Roa, Tania, Lahti, Jari, Räikkönen, Katri, Eriksson, Johan G., Drake, Amanda J., Waldenberger, Melanie, Wahl, Simone, Kunze, Sonja, Lucae, Susanne, Bradley, Bekh, Gieger, Christian, Hausch, Felix, Smith, Alicia K., Ressler, Kerry J., Müller-Myhsok, Bertram, Ladwig, Karl-Heinz, Rein, Theo, Gassen, Nils C., Binder, Elisabeth B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561294/
https://www.ncbi.nlm.nih.gov/pubmed/31113877
http://dx.doi.org/10.1073/pnas.1816847116

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