Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation

Fibroblast growth factor (FGF) 23 produced by bone is a hormone that decreases serum phosphate (Pi). Reflecting its central role in Pi control, serum FGF23 is tightly regulated by serum Pi alterations. FGF23 levels are regulated by the transcriptional event and posttranslational cleavage into inacti...

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Detalles Bibliográficos
Autores principales: Takashi, Yuichi, Kosako, Hidetaka, Sawatsubashi, Shun, Kinoshita, Yuka, Ito, Nobuaki, Tsoumpra, Maria K., Nangaku, Masaomi, Abe, Masahiro, Matsuhisa, Munehide, Kato, Shigeaki, Matsumoto, Toshio, Fukumoto, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561303/
https://www.ncbi.nlm.nih.gov/pubmed/31097591
http://dx.doi.org/10.1073/pnas.1815166116

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