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FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis

The expression patterns of the transcription factor FOXP2 in the developing mammalian forebrain have been described, and some studies have tested the role of this protein in the development and function of specific forebrain circuits by diverse methods and in multiple species. Clinically, mutations...

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Autores principales: Kast, Ryan J, Lanjewar, Alexandra L, Smith, Colton D, Levitt, Pat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561705/
https://www.ncbi.nlm.nih.gov/pubmed/31099752
http://dx.doi.org/10.7554/eLife.42012
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author Kast, Ryan J
Lanjewar, Alexandra L
Smith, Colton D
Levitt, Pat
author_facet Kast, Ryan J
Lanjewar, Alexandra L
Smith, Colton D
Levitt, Pat
author_sort Kast, Ryan J
collection PubMed
description The expression patterns of the transcription factor FOXP2 in the developing mammalian forebrain have been described, and some studies have tested the role of this protein in the development and function of specific forebrain circuits by diverse methods and in multiple species. Clinically, mutations in FOXP2 are associated with severe developmental speech disturbances, and molecular studies indicate that impairment of Foxp2 may lead to dysregulation of genes involved in forebrain histogenesis. Here, anatomical and molecular phenotypes of the cortical neuron populations that express FOXP2 were characterized in mice. Additionally, Foxp2 was removed from the developing mouse cortex at different prenatal ages using two Cre-recombinase driver lines. Detailed molecular and circuit analyses were undertaken to identify potential disruptions of development. Surprisingly, the results demonstrate that Foxp2 function is not required for many functions that it has been proposed to regulate, and therefore plays a more limited role in cortical development than previously thought.
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spelling pubmed-65617052019-06-13 FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis Kast, Ryan J Lanjewar, Alexandra L Smith, Colton D Levitt, Pat eLife Developmental Biology The expression patterns of the transcription factor FOXP2 in the developing mammalian forebrain have been described, and some studies have tested the role of this protein in the development and function of specific forebrain circuits by diverse methods and in multiple species. Clinically, mutations in FOXP2 are associated with severe developmental speech disturbances, and molecular studies indicate that impairment of Foxp2 may lead to dysregulation of genes involved in forebrain histogenesis. Here, anatomical and molecular phenotypes of the cortical neuron populations that express FOXP2 were characterized in mice. Additionally, Foxp2 was removed from the developing mouse cortex at different prenatal ages using two Cre-recombinase driver lines. Detailed molecular and circuit analyses were undertaken to identify potential disruptions of development. Surprisingly, the results demonstrate that Foxp2 function is not required for many functions that it has been proposed to regulate, and therefore plays a more limited role in cortical development than previously thought. eLife Sciences Publications, Ltd 2019-05-17 /pmc/articles/PMC6561705/ /pubmed/31099752 http://dx.doi.org/10.7554/eLife.42012 Text en © 2019, Kast et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology
Kast, Ryan J
Lanjewar, Alexandra L
Smith, Colton D
Levitt, Pat
FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
title FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
title_full FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
title_fullStr FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
title_full_unstemmed FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
title_short FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
title_sort foxp2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
topic Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561705/
https://www.ncbi.nlm.nih.gov/pubmed/31099752
http://dx.doi.org/10.7554/eLife.42012
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