Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis

Mucorales are fungal pathogens that cause mucormycosis, a lethal angioinvasive disease. Previously, we demonstrated that Rhizopus, the most common cause of mucormycosis, invades endothelial cells by binding of its CotH proteins to the host receptor GRP78. Loss of CotH3 renders the fungus noninvasive...

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Detalles Bibliográficos
Autores principales: Gebremariam, Teclegiorgis, Alkhazraji, Sondus, Soliman, Sameh S. M., Gu, Yiyou, Jeon, Heewon H., Zhang, Lina, French, Samuel W., Stevens, David A., Edwards, John E., Filler, Scott G., Uppuluri, Priya, Ibrahim, Ashraf S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561750/
https://www.ncbi.nlm.nih.gov/pubmed/31206021
http://dx.doi.org/10.1126/sciadv.aaw1327

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