Cancer cell killing by target antigen engagement with engineered complementary intracellular antibody single domains fused to pro-caspase3

Many tumour causing proteins, such as those expressed after chromosomal translocations or from point mutations, are intracellular and are not enzymes per se amenable to conventional drug targeting. We previously demonstrated an approach (Antibody-antigen Interaction Dependent Apoptosis (AIDA)) where...

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Detalles Bibliográficos
Autores principales: Chambers, Jennifer S., Brend, Tim, Rabbitts, Terence H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561968/
https://www.ncbi.nlm.nih.gov/pubmed/31189945
http://dx.doi.org/10.1038/s41598-019-44908-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561968/
https://www.ncbi.nlm.nih.gov/pubmed/31189945
http://dx.doi.org/10.1038/s41598-019-44908-7

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